ArticleCirculation2018
Regulatory CD4
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In one paragraph
Article in Circulation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 129 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
129citing papers in PubMed, 2 pooled it
7.0field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
129 citing papers in PubMed, 2 syntheses or guidelines pooled it, 165 citations in OpenAlex.
- Influenza vaccination and the risk of myocardial infarction: a meta-epidemiology study.BMC public health · 2026Pooled it
- Meta-Analysis of Leukocyte Diversity in Atherosclerotic Mouse Aortas.Circulation research · 2020Pooled it
- Heart-specific T cell responses: from antigens to disease mechanisms.Nature reviews. Cardiology · 2026Review
- Checkpoint inhibitors create rogue regulatory T cells.The Journal of clinical investigation · 2026Article
- Regulatory T cells in cancer and inflammation.Signal transduction and targeted therapy · 2026Review
- CD8Nature reviews. Cardiology · 2026Review
- T Cell Receptor Repertoires Across the Continuum of Vascular, Myocardial, and Age-Related Diseases.Immunological reviews · 2026Review
- Lipid-based nanosystems for atherosclerosis treatment: Evolving approaches and novel therapeutic strategies.Acta pharmaceutica Sinica. B · 2026Review
- Rising cardiovascular metabolic indices are associated with hypertension and stroke risk in individuals with abnormal glucose metabolism: A prospective cohort study.Aging clinical and experimental research · 2026Article
- Single-cell Transcriptomic Profiling Reveals Diagnostic of T Cell-platelet Aggregates in Peripheral Blood for Coronary Vulnerable Plaques.Journal of cardiovascular translational research · 2026Article
- Review
- T cells in cardiovascular disease: solved and unsolved mysteries.Science China. Life sciences · 2026Review
- ApoB-specific CD4Frontiers in immunology · 2026Review
- Relationships Between Circulating Lipids, Lipoproteins, and Lymphocyte Subsets in the Multi-Ethnic Study of Atherosclerosis.Global heart · 2026Article
- Article
- ER stress induced mitochondrial dysfunction drives Treg instability in coronary artery disease.EMBO molecular medicine · 2025Article
- Bacterial Systems as a Precision Delivery Platform of Therapeutic Peptides for Cancer Therapy.Polymer science & technology (Washington, D.C.) · 2025Review
- Emergent dynamics of cellular decision making in multi-node mutually repressive regulatory networks.Journal of the Royal Society, Interface · 2025Article
- Loss of effector TNature cardiovascular research · 2025Article
- Research Hotspots and Development Trends on Apolipoprotein B in the Field of Atherosclerosis: A Bibliometric Analysis.Molecular biotechnology · 2025Review
69 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors at 1 institution in 1 country.
Takayuki KimuraDivision of Inflammation Biology, La Jolla Institute for Allergy and Immunology, CA (T.K., K.K., H.W., K.T., J.M., M.V., D.W., C.R., M.O., K.L.).
Kouji KobiyamaDivision of Inflammation Biology, La Jolla Institute for Allergy and Immunology, CA (T.K., K.K., H.W., K.T., J.M., M.V., D.W., C.R., M.O., K.L.).
Holger WinkelsDivision of Inflammation Biology, La Jolla Institute for Allergy and Immunology, CA (T.K., K.K., H.W., K.T., J.M., M.V., D.W., C.R., M.O., K.L.).
Kevin TseDivision of Inflammation Biology, La Jolla Institute for Allergy and Immunology, CA (T.K., K.K., H.W., K.T., J.M., M.V., D.W., C.R., M.O., K.L.).
Jacqueline MillerDivision of Inflammation Biology, La Jolla Institute for Allergy and Immunology, CA (T.K., K.K., H.W., K.T., J.M., M.V., D.W., C.R., M.O., K.L.).
Melanie VassalloDivision of Inflammation Biology, La Jolla Institute for Allergy and Immunology, CA (T.K., K.K., H.W., K.T., J.M., M.V., D.W., C.R., M.O., K.L.).
Dennis WolfDivision of Inflammation Biology, La Jolla Institute for Allergy and Immunology, CA (T.K., K.K., H.W., K.T., J.M., M.V., D.W., C.R., M.O., K.L.).
Christian RydenDivision of Inflammation Biology, La Jolla Institute for Allergy and Immunology, CA (T.K., K.K., H.W., K.T., J.M., M.V., D.W., C.R., M.O., K.L.).
Marco OrecchioniDivision of Inflammation Biology, La Jolla Institute for Allergy and Immunology, CA (T.K., K.K., H.W., K.T., J.M., M.V., D.W., C.R., M.O., K.L.).
Thamotharampillai DileepanDepartment of Microbiology, University of Minnesota Medical School, Minneapolis (T.D., M.K.J.).
Marc K JenkinsDepartment of Microbiology, University of Minnesota Medical School, Minneapolis (T.D., M.K.J.).
Eddie A JamesTetramer Core Laboratory, Benaroya Research Institute at Virginia Mason, Seattle, WA (E.A.J., W.W.K.).
William W KwokTetramer Core Laboratory, Benaroya Research Institute at Virginia Mason, Seattle, WA (E.A.J., W.W.K.).
David B HannaDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (D.B.H., R.C.K., H.D.S.).
Robert C KaplanDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (D.B.H., R.C.K., H.D.S.).
Howard D StricklerDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (D.B.H., R.C.K., H.D.S.).
Helen G DurkinDepartment of Pathology, SUNY Downstate Medical Center, Brooklyn, NY (H.G.D.).
Seble G KassayeDepartment of Medicine, Georgetown University, Washington, DC (S.G.K.).
Roksana KarimDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles (R.K.).
Phyllis C TienDepartment of Medicine, University of California, San Francisco (P.C.T.).
Alan L LandayDepartment of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, IL (A.L.L.).
Stephen J GangeDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (S.J.G.).
John SidneyDivision of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, CA (J.S., A.S.).
Alessandro SetteDivision of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, CA (J.S., A.S.).
Klaus LeyDepartment of Bioengineering, University of California, San Diego, La Jolla (K.L.).
University of California, San Francisco · US
Funding
Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0MWomen's Interagency HIV Study (WIHS-V)U01AI035004 · NIAID · MONTEFIORE MEDICAL CENTER (BRONX, NY) · PI ANASTOS, KATHRYN M., SHARMA, ANJALI · 1993 to 2018
$65.7MWOMEN'S INTERAGENCY HIV STUDY ORGANIZATION, MANAGEMENT AND COMMUNICATIONSU01AI034989 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AOUIZERAT, BRADLEY E, GREENBLATT, RUTH MARTHA · 1993 to 2018
$65.6MWomen's Interagency HIV Study (WIHS) IIIU01AI031834 · NIAID · SUNY DOWNSTATE MEDICAL CENTER · PI GUSTAFSON, DEBORAH R., MINKOFF, HOWARD · 1998 to 2018
$53.5MWOMEN'S INTERAGENCY HIV STUDY (WIHS) ORGANIZATION AND MANAGEMENTU01AI034994 · NIAID · GEORGETOWN UNIVERSITY · PI KASSAYE, SEBLE G · 1993 to 2018
$52.0MWomen's Interagency HIV Study (WIHS) IV, Chicago ConsortiumU01AI034993 · NIAID · HEKTOEN INSTITUTE FOR MEDICAL RESEARCH · PI COHEN, MARDGE H, FRENCH, AUDREY · 1994 to 2018
$51.0MWOMENS INTERAGENCY HIV STUDY (WIHS)U01HD032632 · NICHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MILAM, JOEL E · 1994 to 2012
$42.0MWIHS DATA MANAGEMENT AND ANALYSIS CENTER(WDMAC)U01AI042590 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GANGE, STEPHEN J, GOLUB, ELIZABETH T · 1998 to 2018
$38.4MAtlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8MProject 4: APOB-specific CD4 and CD8 T cells exacerbate atherosclerosisP01HL136275 · NHLBI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Catherine C Hedrick · 2017 to 2026
$25.5MEmory WIHS CRS - Longitudinal CohortU01AI103408 · NIAID · EMORY UNIVERSITY · PI OFOTOKUN, IGHOVWERHA, WINGOOD, GINA MARIA · 2013 to 2018
$14.1MUAB-MISS WIHS CohortU01AI103401 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KEMPF, MIRJAM-COLETTE, KONKLE-PARKER, DEBORAH J · 2013 to 2018
$11.2MNHLBI NIH HHS K01 HL137557NHLBI NIH HHS P01 HL136275NHLBI NIH HHS R01 HL083760NHLBI NIH HHS R01 HL095140NHLBI NIH HHS R01 HL121697NHLBI NIH HHS R01 HL126543NIAID NIH HHS U01 AI031834NIAID NIH HHS U01 AI034989NIAID NIH HHS U01 AI034993NIAID NIH HHS U01 AI034994NIAID NIH HHS U01 AI035004NIAID NIH HHS U01 AI042590NIAID NIH HHS U01 AI103390NIAID NIH HHS U01 AI103397NIAID NIH HHS U01 AI103401NIAID NIH HHS U01 AI103408NICHD NIH HHS U01 HD032632
Abstract
backgroundCD4
methodsWe constructed p18 tetramers to detect human and mouse APOB-specific T cells and assayed their phenotype by flow cytometry including CD4 lineage transcription factors, intracellular cytokines, and T cell receptor activation. Apolipoprotein E-deficient ( Apoe
resultsIn human peripheral blood mononuclear cells from donors without cardiovascular disease, p18 specific CD4
conclusionsThese findings show that APOB p18-specific CD4
Indexed as
Adjuvants, ImmunologicAnimalsAortaAortic DiseasesApolipoprotein B-100Apolipoproteins BAtherosclerosisDisease Models, AnimalEpitope MappingEpitopes, T-LymphocyteFemaleFreund's AdjuvantHistocompatibility Antigens Class IIHumansLymphocyte ActivationMaleAdjuvants, ImmunologicAPOB protein, humanApob protein, mouseApolipoprotein B-100Apolipoproteins BEpitopes, T-LymphocyteFreund's AdjuvantHistocompatibility Antigens Class IIPeptide Fragmentsantigen specificityapoB-100atherosclerosisregulatory T cellsvaccination
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.