Evidence map›Paper›PMID 29588311›Full record

Observational studyJournal of the American Heart Association2018

Risk of Stroke or Death Is Associated With the Timing of Carotid Artery Stenting for Symptomatic Carotid Stenosis: A Secondary Data Analysis of the German Statutory Quality Assurance Database.

Pavlos Tsantilas, Andreas Kuehnl, Michael Kallmayer, Christoph Knappich, Sofie Schmid, Thorben Breitkreuz, Alexander Zimmermann, Hans-Henning Eckstein

Erratum issuedOpen access · goldAbstract readObservational Study
In one paragraph

Observational study in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. CIRSE Standards of Practice on Carotid Artery Stenting.Cardiovascular and interventional radiology · 2024
    Guideline
  2. Article
  3. Article
  4. Article
  5. Article
  6. Safety and efficacy of symptomatic carotid artery stenting performed in an emergency setting.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2021
    Article
  7. Article
  8. Article
  9. Article
  10. Observational
  11. Observational
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Pavlos TsantilasDepartment of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University Munich, Germany.
Andreas KuehnlDepartment of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University Munich, Germany.
Michael KallmayerDepartment of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University Munich, Germany.
Christoph KnappichDepartment of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University Munich, Germany.
Sofie SchmidDepartment of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University Munich, Germany.
Thorben BreitkreuzaQua-Institute for Applied Quality Improvement and Research in Health GmbH, Göttingen, Germany.
Alexander ZimmermannDepartment of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University Munich, Germany.
Hans-Henning EcksteinDepartment of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University Munich, Germany hans-henning.eckstein@mri.tum.de.
Klinikum rechts der Isar · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSubgroup analyses from randomized trials indicate that the time interval between the neurologic index event and carotid artery stenting is associated with periprocedural stroke and death rates in patients with symptomatic carotid stenosis. The aim of this article is to analyze whether this observation holds true under routine conditions in Germany. METHODS AND

resultsSecondary data analysis was done on 4717 elective carotid artery stenting procedures that were performed for symptomatic carotid stenosis. The patient cohort was divided into 4 groups according to the time interval between the index event and intervention (group I 0-2, II 3-7, III 8-14, and IV 15-180 days). Primary outcome was any in-hospital stroke or death. For risk-adjusted analyses, a multilevel multivariable regression model was used. The in-hospital stroke or death rate was 3.7% in total and 6.0%, 4.4%, 2.4%, and 3.0% in groups I, II, III, and IV, respectively. Adjusted analysis showed a decreased risk for any stroke or death in group III, a decreased risk for any major stroke or death in groups III and IV, and a decreased risk for any death in groups II and III compared to the reference group I.

conclusionsA short time interval between the neurologic index event and carotid artery stenting of up to 7 days is associated with an increased risk for stroke or death under routine conditions in Germany. Although results cannot prove causal relationships, carotid artery stenting may be accompanied by an increased risk of stroke or death during the early period after the index event.

Indexed as

StentsTime-to-TreatmentAgedAngioplastyCarotid StenosisClinical Decision-MakingDatabases, FactualFemaleGermanyHospital MortalityHumansMaleMiddle AgedQuality Assurance, Health CareRetrospective StudiesRisk Assessmentamaurosis fugaxcarotid stenosiscarotid stentingcohortnationwideperi‐interventional outcomestroketime intervaltransient ischemic attack

Identifiers

PMID29588311
PMCPMC5907586
OpenAlexW2794936825

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.