ArticleBrain, behavior, and immunity2018
Associations between maternal cytokine levels during gestation and measures of child cognitive abilities and executive functioning.
Article in Brain, behavior, and immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed.
- Persistent priming of hypothalamic microglia is associated with sensitization of the hypothalamic-pituitary-adrenal axis to acute stress, hyperactivity and behavioral response disruption in male rats.Frontiers in immunology · 2026Article
- Decreased hippocampal neurite density in late-middle-aged adults following prenatal exposure to higher levels of maternal inflammation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Decreased hippocampal neurite density in late middle-aged adults following prenatal exposure to higher levels of maternal inflammation.bioRxiv : the preprint server for biology · 2025Article
- Prenatal chronic inflammation and children's executive function development.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2025Article
- Maternal interleukin 6 in pregnancy is associated withPsychological medicine · 2025Article
- Understanding the potential impact of trimester-specific maternal immune activation due to SARS-CoV-2 on early human neurodevelopment and the role of cytokine balance.Brain, behavior, & immunity - health · 2025Article
- Maternal immune response during pregnancy and neurodevelopmental outcomes: A longitudinal approach.Brain, behavior, & immunity - health · 2024Article
- Prenatal maternal Inflammation, childhood cognition and adolescent depressive symptoms.Brain, behavior, and immunity · 2024Article
- Viral infections in pregnancy and impact on offspring neurodevelopment: mechanisms and lessons learned.Pediatric research · 2024Review
- Distinct cytokine profiles in late pregnancy in Ugandan people with HIV.Scientific reports · 2024Article
- IL-8 (CXCL8) Correlations with Psychoneuroimmunological Processes and Neuropsychiatric Conditions.Journal of personalized medicine · 2024Review
- Placental inflammatory cytokines mRNA expression and preschool children's cognitive performance: a birth cohort study in China.BMC medicine · 2023Article
- Sex-Specific Dysconnective Brain Injuries and Neuropsychiatric Conditions such as Autism Spectrum Disorder Caused by Group BInternational journal of molecular sciences · 2023Review
- Maternal obesity, gestational diabetes mellitus, and diet in association with neurodevelopment of 2-year-old children.Pediatric research · 2023Article
- Maternal infections during pregnancy and child cognitive outcomes.BMC pregnancy and childbirth · 2022Article
- Testing a cascade model linking prenatal inflammation to child executive function.Behavioural brain research · 2022Article
- Shuffle the Decks: Children Are Sensitive to Incidental Nonrandom Structure in a Sequential-Choice Task.Psychological science · 2022Article
- Associations Between Eczema and Attention Deficit Hyperactivity Disorder Symptoms in Children.Frontiers in pediatrics · 2022Article
- Associations between T cells and attention problems in the general pediatric population: The Generation R study.JCPP advances · 2021Article
- Impact of prenatal maternal cytokine exposure on sex differences in brain circuitry regulating stress in offspring 45 years later.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
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Authors and funding
10 authors.
Funding
Abstract
Preclinical studies demonstrate that environmentally-induced alterations in inflammatory cytokines generated by the maternal and fetal immune system can significantly impact fetal brain development. Yet, the relationship between maternal cytokines during gestation and later cognitive ability and executive function remains understudied. Children (n = 246) were born of mothers enrolled in the Newborn Epigenetic Study - a prospective pre-birth cohort in the Southeastern US. We characterized seven cytokines [IL-1β, IL-4,IL-6, IL-12p70, IL-17A, tumor necrosis factor-α (TNFα), and interferon-γ (IFNγ)] and one chemokine (IL-8) from maternal plasma collected during pregnancy. We assessed children's cognitive abilities and executive functioning at a mean age of 4.5 (SD = 1.1) years. Children's DAS-II and NIH toolbox scores were regressed on cytokines and the chemokine, controlling for maternal age, race, education, body mass index, IQ, parity, smoking status, delivery type, gestational weeks, and child birth weight and sex. Higher IL-12p70 (β
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