Evidence map›Paper›PMID 29588218›Full record

ArticleMitochondrion2019

Alloreactivity and allorecognition of syngeneic and allogeneic mitochondria.

Giovanna Ramirez-Barbieri, Kamila Moskowitzova, Borami Shin, David Blitzer, Arzoo Orfany, Alvise Guariento, Khadija Iken, Ingeborg Friehs, David Zurakowski, Pedro J Del Nido and 1 more

Registry-linked trialAbstract read
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In one paragraph

Article in Mitochondrion, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04998357 (Study Title), which is not on this map. Cited by 73 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04998357 narecruitingnot on this mapstarted 2021, after this paper: background citation

Study Title: Autologous Mitochondrial Transplant for Cerebral Ischemia

TypeinterventionalSponsorUniversity of WashingtonRan2021 to 2026Enrolled20ConditionsCerebral IschemiaArmsEndovascular autologous mitochondrial transplantation
3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  11. Therapeutic Potential of Mitochondrial Transplantation with Focus on DBD.International journal of molecular sciences · 2026
    Review
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  13. Article
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  15. Mitochondrial Transplantation as a Therapeutic Strategy for Inherited Mitochondrial Diseases.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  16. Article
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13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Giovanna Ramirez-BarbieriDepartment of Cardiac Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.
Kamila MoskowitzovaDepartment of Cardiac Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.
Borami ShinDepartment of Cardiac Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.
David BlitzerDepartment of Cardiac Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.
Arzoo OrfanyDepartment of Cardiac Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.
Alvise GuarientoDepartment of Cardiac Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.
Khadija IkenDepartment of Pulmonary Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.
Ingeborg FriehsDepartment of Cardiac Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.
David ZurakowskiDepartment of Cardiac Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.
Pedro J Del NidoDepartment of Cardiac Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.
James D McCullyDepartment of Cardiac Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States. Electronic address: james_mccully@hms.harvard.edu.

Funding

HARVARD-LONGWOOD RESEARCH TRAINING IN VASCULAR SURGERYT32HL007734 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI FERRAN, CHRISTIANE, LOGERFO, FRANK W · 1993 to 2023
$10.5M
NHLBI NIH HHS T32 HL007734
6 · The paper itself

Abstract

Previously, we have demonstrated that the transplantation of autologous mitochondria is cardioprotective. No immune or autoimmune response was detectable following the single injection of autologous mitochondria. To expand the therapeutic potential and safety of mitochondrial transplantation, we now investigate the immune response to single and serial injections of syngeneic and allogeneic mitochondria delivered by intraperitoneal injection. Our results demonstrate that there is no direct or indirect, acute or chronic alloreactivity, allorecognition or damage-associated molecular pattern molecules (DAMPs) reaction to single or serial injections of either syngeneic or allogeneic mitochondria.

Indexed as

Transplantation, HomologousAnimalsFemaleInjections, IntraperitonealIsoantigensMice, Inbred BALB CMice, Inbred C57BLMitochondriaTransplantation, IsogeneicIsoantigensAllogeneicAlloreactivityImmune responseMitochondriaSkin allograftSyngeneic allogeneic

Identifiers

PMID29588218

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.