Evidence map›Paper›PMID 29588157›Full record

ReviewSeminars in cell & developmental biology2019

Gp2.5, the multifunctional bacteriophage T7 single-stranded DNA binding protein.

Alfredo J Hernandez, Charles C Richardson

Open access · greenAbstract readReview
In one paragraph

Review in Seminars in cell & developmental biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 42 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Alfredo J HernandezDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
Charles C RichardsonDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA. Electronic address: ccr@hms.harvard.edu.
Harvard University · US

Funding

STRUCTURE AND SYNTHESIS OF DNAR01GM054397 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI RICHARDSON, CHARLES C. · 1996 to 2011
$7.6M
Primer Synthesis and Handoff by Bacteriophage T7 DNA PrimaseF32GM101761 · NIGMS · HARVARD MEDICAL SCHOOL · PI HERNANDEZ, ALFREDO J · 2012 to 2014
$150k
NIGMS NIH HHS F32 GM101761NIGMS NIH HHS R01 GM054397
6 · The paper itself

Abstract

The essential bacteriophage T7-encoded single-stranded DNA binding protein is the nexus of T7 DNA metabolism. Multiple layers of macromolecular interactions mediate its function in replication, recombination, repair, and the maturation of viral genomes. In addition to binding ssDNA, the protein binds to DNA polymerase and DNA helicase, regulating their activities. The protein displays potent homologous DNA annealing activity, underscoring its role in recombination.

Indexed as

Bacteriophage T7DNA-Binding ProteinsDNA ReplicationDNA, ViralDNA-Binding ProteinsDNA, ViralBacteriophage T7DNA replication annealingHomologousRecombinationSingle-stranded DNA binding protein

Identifiers

PMID29588157
PMCPMC6162179
OpenAlexW2795350756

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.