ArticleJournal of the American Academy of Child and Adolescent Psychiatry2018
Data-Driven Subtyping of Executive Function-Related Behavioral Problems in Children.
Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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38 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- A Systematic Review of the Validity and Reliability of Assessment Tools for Executive Function and Adaptive Function Following Brain Pathology among Children and Adolescents in Low- and Middle-Income Countries.Neuropsychology review · 2022Pooled it
- The cingulum as a marker of individual differences in neurocognitive development.Scientific reports · 2019Trial
- Transdiagnostic profiles of socio-affective functioning in adolescents at-risk of poor mental health.JCPP advances · 2026Article
- ADHD and intelligence polygenic scores associations with developmental dimensions in children with attention, learning and memory difficulties.European child & adolescent psychiatry · 2026Article
- A new approach to assessment for young children referred by education professionals for socio-emotional, behavioural, and cognitive difficulties.JCPP advances · 2026Article
- Sex-specific association between maternal integrative endocrine and metabolic status during pregnancy and preschoolers' emotional-behavioral development: A birth cohort study.European child & adolescent psychiatry · 2026Article
- Cognitive Profiles are Better Predictors of Literacy Attainment Than Diagnostic Outcomes in Children with High ADHD Symptoms.Journal of autism and developmental disorders · 2025Article
- Mediating Effects of Executive Function on the Relationship between Sleep Problems and Emotional and Behavioral Problems among Preschoolers: Physical Activity as a Protective Factor.Child psychiatry and human development · 2025Article
- Theory of mind and psychopathology: The differential impact of temperament group membership.Journal of child and family studies · 2025Article
- Exploring functional connectivity in clinical and data-driven groups of preterm and term adults.Brain communications · 2025Article
- Neurodevelopmental subtypes of functional brain organization in the ABCD study using a rigorous analytic framework.NeuroImage · 2024Article
- Neurodevelopmental Subtypes of Functional Brain Organization in the ABCD Study Using a Rigorous Analytic Framework.bioRxiv : the preprint server for biology · 2024Article
- Attention and motor profiles in children with developmental coordination disorder: A neuropsychological and neuroimaging investigation.Developmental medicine and child neurology · 2024Article
- Probing the overarching continuum theory: data-driven phenotypic clustering of children with ASD or ADHD.European child & adolescent psychiatry · 2023Article
- Clinical subtyping using community detection: Limited utility?International journal of methods in psychiatric research · 2023Article
- Transdiagnostic profiles of behaviour and communication relate to academic and socioemotional functioning and neural white matter organisation.Journal of child psychology and psychiatry, and allied disciplines · 2023Article
- Examining normative values using the Cambridge neuropsychological test automated battery and developmental traits of executive functions among elementary school-aged children in Japan.Frontiers in psychology · 2023Article
- Testing the triple network model of psychopathology in a transdiagnostic neurodevelopmental cohort.NeuroImage. Clinical · 2023Article
- Joint Consideration of Inhibitory Control and Irritability in Young Children: Contributions to Emergent Psychopathology.Research on child and adolescent psychopathology · 2022Article
- Assessment Tools for Executive Function and Adaptive Function Following Brain Pathology Among Children in Developing Country Contexts: a Scoping Review of Current Tools.Neuropsychology review · 2022Article
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4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveExecutive functions (EF) are cognitive skills that are important for regulating behavior and for achieving goals. Executive function deficits are common in children who struggle in school and are associated with multiple neurodevelopmental disorders. However, there is also considerable heterogeneity across children, even within diagnostic categories. This study took a data-driven approach to identify distinct clusters of children with common profiles of EF-related difficulties, and then identified patterns of brain organization that distinguish these data-driven groups.
methodThe sample consisted of 442 children identified by health and educational professionals as having difficulties in attention, learning, and/or memory. We applied community clustering, a data-driven clustering algorithm, to group children by similarities on a commonly used rating scale of EF-associated behavioral difficulties, the Conners 3 questionnaire. We then investigated whether the groups identified by the algorithm could be distinguished on white matter connectivity using a structural connectomics approach combined with partial least squares analysis.
resultsThe data-driven clustering yielded 3 distinct groups of children with symptoms of one of the following: (1) elevated inattention and hyperactivity/impulsivity, and poor EF; (2) learning problems; or (3) aggressive behavior and problems with peer relationships. These groups were associated with significant interindividual variation in white matter connectivity of the prefrontal and anterior cingulate cortices.
conclusionIn sum, data-driven classification of EF-related behavioral difficulties identified stable groups of children, provided a good account of interindividual differences, and aligned closely with underlying neurobiological substrates.
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