Evidence map›Paper›PMID 29588030›Full record

ArticleMethods in enzymology2018

The Mouse as a Model Organism for Assessing Anesthetic Sensitivity.

Andrzej Z Wasilczuk, Kaitlyn L Maier, Max B Kelz

Abstract read
In one paragraph

Article in Methods in enzymology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Sex-specific developmental phenotypes and their response to neonatalbioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Activation of CaMKIICell biology and toxicology · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Hormonal basis of sex differences in anesthetic sensitivity.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  12. Article
  13. The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Andrzej Z WasilczukUniversity of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, United States.
Kaitlyn L MaierUniversity of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, United States.
Max B KelzUniversity of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, United States; Center for Sleep and Circadian Neurobiology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, United States. Electronic address: kelz@pennmedicine.upenn.edu.

Funding

NEURONAL BASIS UNDERLYING VOLATILE ANESTHETIC INDUCED HYPNOSISR01GM088156 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI KELZ, MAX · 2010 to 2021
$3.8M
OptoanesthesiaR01GM107117 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI KELZ, MAX · 2014 to 2017
$1.3M
NIGMS NIH HHS R01 GM088156NIGMS NIH HHS R01 GM107117
6 · The paper itself

Abstract

The mouse has been used in many medical fields as a powerful model to reveal the genetic basis of human physiology and disease. The past two decades have witnessed an enormous wealth of genetic and informatic resources dedicated to this humble organism. With the ongoing revolution in mapping neural circuitry governing behavior, the mouse is an ideal model organism poised to unravel the mysteries of general anesthetic action. This chapter will describe and provide guidelines for anesthetic phenotyping in the mouse including both motor-dependent and motor-independent assessments.

Indexed as

Behavior Rating ScaleAnestheticsAnimalsBehavior, AnimalConsciousnessDose-Response Relationship, DrugElectromyographyHumansImage Processing, Computer-AssistedMiceModels, AnimalMovementSoftwareVideo RecordingAnestheticsElectroencephalographyElectromyographyHypnosisPharmacodynamicPharmacokineticSedation

Identifiers

PMID29588030
PMCPMC6880744

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.