ArticleBMC research notes2018
Cytokeratin 5/6 expression in bladder cancer: association with clinicopathologic parameters and prognosis.
Article in BMC research notes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Computational pathology model to predict recurrence-free survival in NMPUC patients on BCG-therapy.NPJ precision oncology · 2026Article
- Prognostic Significance of CK5/6 and GATA3 Expression in Recurrent Urothelial Carcinoma.Cancers · 2025Article
- Observational
- Identification of Molecular Subgroups of Muscle-Invasive Urothelial Bladder Cancer and Their Impact on Treatment Outcome.Asian Pacific journal of cancer prevention : APJCP · 2024Article
- Article
- Renal pelvic plasmacytoid subtype urothelial carcinoma accompanied with solitary mammary metastasis.International cancer conference journal · 2024Article
- Are We Ready to Implement Molecular Subtyping of Bladder Cancer in Clinical Practice? Part 1: General Issues and Marker Expression.International journal of molecular sciences · 2022Review
- Cytokeratin 5 and cytokeratin 6 expressions are unconnected in normal and cancerous tissues and have separate diagnostic implications.Virchows Archiv : an international journal of pathology · 2022Article
- (Pro)renin Receptor Is a Novel Independent Prognostic Marker in Invasive Urothelial Carcinoma of the Bladder.Cancers · 2021Article
- Impact of immunohistochemistry-based subtyping of GATA3, CK20, CK5/6, and CK14 expression on survival after radical cystectomy for muscle-invasive bladder cancer.Scientific reports · 2021Article
- Establishment of a bladder cancer cell line expressing both mesenchymal and epithelial lineage-associated markers.Human cell · 2021Article
- Prognostic Implications of Deep Muscle Invasion and High Grade for Bladder Urothelial Carcinoma.Cureus · 2020Article
- CK20 and CK5/6 Immunohistochemical Staining of Urothelial Neoplasms: A Perspective.Advances in urology · 2020Review
- Single Cell Mechanotype and Associated Molecular Changes in Urothelial Cell Transformation and Progression.Frontiers in cell and developmental biology · 2020Article
- Rapid testicular metastasis from bladder transitional urothelial carcinoma after radical cystoprostatectomy: A case report.Medicine · 2019Article
- Primary non-urothelial squamous cell carcinoma masquerading as a perforated gastric ulcer: a case report.Journal of surgical case reports · 2019Article
- Cytokeratin 5/6 and cytokeratin 8/18 expression in triple negative breast cancers: clinicopathologic significance in South-Asian population.BMC research notes · 2018Article
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7 authors.
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Abstract
objectivesWell differentiated keratinized squamous component as a part of urothelial carcinoma can be easily appreciated; however non-keratinizing squamous differentiation closely resembles urothelial differentiation. In addition prognostic significance of CK 5/6 expression in the absence of apparent squamous differentiation is still unclear. Therefore, in the present study we aimed to evaluate the frequency of CK 5/6 expression in 127 cases of urothelial carcinoma and its prognostic significance in loco-regional population.
resultsPositive CK5/6 expression was noted in 6.3% (8 cases) and 13.4% (17 cases) revealed focal positive CK 5/6 expression. On the other hand, 80.3% (102 cases) showed negative CK5/6 staining. Significant association of CK5/6 expression was noted with tumor grade and muscularis propria invasion, however no significant association was noted with overall and disease free survival. On the basis of the results of our study we can conclude that CK5/6 is an independent prognostic biomarker in urothelial carcinoma and therefore can be used in the prognostic stratification of the patients with bladder cancer.
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