ArticleStem cell research & therapy2018
The need to revisit the definition of mesenchymal and adult stem cells based on their functional attributes.
Article in Stem cell research & therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
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- Stem cell transplantation in immuno-hematologic and infectious diseases.World journal of transplantation · 2026Review
- Role of Seminal Exosomes in Reproduction.Journal of cellular physiology · 2025Review
- Mesenchymal Stem Cells and MSCs-Derived Extracellular Vesicles in Infectious Diseases: From Basic Research to Clinical Practice.Bioengineering (Basel, Switzerland) · 2022Review
- Trans-differentiation of mouse mesenchymal stem cells into pancreatic β-like cells by a traditional anti-diabetic medicinal herbJournal of traditional and complementary medicine · 2022Article
- Extruded Nucleoli of Human Dental Pulp Cells.Medicina (Kaunas, Lithuania) · 2022Article
- Editorial: Mesenchymal Stromal Cells: Preclinical and Clinical Challenges.Frontiers in cell and developmental biology · 2022Article
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- Therapeutic Mesenchymal Stem/Stromal Cells: Value, Challenges and Optimization.Frontiers in cell and developmental biology · 2021Review
- Pulmonary Mesenchymal Stem Cells in Mild Cases of COVID-19 Are Dedicated to Proliferation; In Severe Cases, They Control Inflammation, Make Cell Dispersion, and Tissue Regeneration.Frontiers in immunology · 2021Article
- Tissue specific diversity of mesenchymal stem cells - Valuable insights through transcriptome analysis of extracellular vesicles.Journal of stem cells & regenerative medicine · 2021Article
- Role of the CXCR4-SDF1-HMGB1 pathway in the directional migration of cells and regeneration of affected organs.World journal of stem cells · 2020Review
- Human Chorionic Gonadotropin Improves the Proliferation and Regenerative Potential of Bone Marrow Adherent Stem Cells and the Immune Tolerance of Fetal Microchimeric Stem Cells In Vitro.Stem cell reviews and reports · 2020Article
- A comparative in vitro study of the effect of biospecific integrin recognition processes and substrate nanostructure on stem cell 3D spheroid formation.Journal of materials science. Materials in medicine · 2020Article
- Role of Stem-Cell Transplantation in Leukemia Treatment.Stem cells and cloning : advances and applications · 2020Review
- Biological functions of mesenchymal stem cells and clinical implications.Cellular and molecular life sciences : CMLS · 2019Review
- Will iPS Cells Regenerate or Just Provide Trophic Support to the Diseased Tissues?Stem cell reviews and reports · 2018Article
- Gonadotropin and steroid hormones regulate pluripotent very small embryonic-like stem cells in adult mouse uterine endometrium.Journal of ovarian research · 2018Article
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Abstract
A debate is ongoing about the 'stem cell' status of mesenchymal stem cells (MSCs). This can easily be resolved based on the definition of a stem cell. 'True' stem cells are expected to undergo asymmetric cell divisions (ACD) whereby they divide to self-renew and give rise to a slightly bigger, differentiated cell. However, MSCs like any other adult tissue-specific stem cells, including hematopoietic (HSCs), spermatogonial (SSCs) and ovarian (OSCs) stem cells, do not undergo ACD; rather they undergo rapid symmetrical cell divisions. The true stem cells in adult tissues are possibly the pluripotent stem cells termed very small embryonic-like stem cells (VSELs), which were recently shown to undergo ACD to give rise to tissue-specific stem cells 'progenitors' (currently termed 'adult stem cells') that in turn undergo rapid symmetric cell divisions and clonal expansion (sphere formation with incomplete cytokinesis) followed by differentiation into tissue-specific cell types. MSCs can be cultured from any tissue source and are an excellent source of growth factors/cytokines and thus could provide a niche for proper functioning of the stem/progenitor cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.