Evidence map›Paper›PMID 29587764›Full record

ArticleJournal of nanobiotechnology2018

pH-responsive theranostic nanocomposites as synergistically enhancing positive and negative magnetic resonance imaging contrast agents.

Xi Huang, Yaping Yuan, Weiwei Ruan, Lianhua Liu, Maili Liu, Shizhen Chen, Xin Zhou

Abstract read
In one paragraph

Article in Journal of nanobiotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xi HuangState Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences; Wuhan National Laboratory for Optoelectronics, Wuhan, 430071, China.
Yaping YuanState Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences; Wuhan National Laboratory for Optoelectronics, Wuhan, 430071, China.
Weiwei RuanState Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences; Wuhan National Laboratory for Optoelectronics, Wuhan, 430071, China.
Lianhua LiuState Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences; Wuhan National Laboratory for Optoelectronics, Wuhan, 430071, China.
Maili LiuState Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences; Wuhan National Laboratory for Optoelectronics, Wuhan, 430071, China.
Shizhen ChenState Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences; Wuhan National Laboratory for Optoelectronics, Wuhan, 430071, China. chenshizhen@wipm.ac.cn.
Xin ZhouState Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences; Wuhan National Laboratory for Optoelectronics, Wuhan, 430071, China. xinzhou@wipm.ac.cn.ORCID http://orcid.org/0000-0002-5580-7907

Funding

National Natural Science Foundation of China 21575157National Natural Science Foundation of China 81227902National Natural Science Foundation of China 81625011
6 · The paper itself

Abstract

backgroundThe rational design of theranostic nanoprobe to present responsive effect of therapeutic potency and enhanced diagnostic imaging in tumor milieu plays a vital role for efficient personalized cancer therapy and other biomedical applications. We aimed to afford a potential strategy to pose both T

resultsTheranostic nanocomposites Mn-porphyrin&Fe

conclusionThe synthesized nanocomposites exhibited highly sensitive MRI contrast function no matter in solution, cells or in vivo by synergistically enhancing positive and negative magnetic resonance imaging signals. The nanocomposites showed great potential for integrating imaging diagnosis and drug controlled release into one composition and providing real-time imaging with greatly enhanced diagnostic accuracy during targeted therapy.

Indexed as

A549 CellsAnimalsCarcinoma, Non-Small-Cell LungContrast MediaDoxorubicinDrug CompoundingFerrosoferric OxideHumansHydrogen-Ion ConcentrationLung NeoplasmsMagnetic Resonance ImagingMaleManganeseMiceMice, NudeNanocompositesarginyl-glycyl-aspartic acidContrast MediaDoxorubicinFerrosoferric OxideManganeseOligopeptidesPorphyrinsSilicon DioxideContrast agentsLung cancerMagnetic resonance imagingT1/T2 dual-modeTheranostic nanoprobe

Identifiers

PMID29587764
PMCPMC5870481

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.