ArticleEnvironmental health : a global access science source2018
Exposure to hazardous air pollutants and risk of incident breast cancer in the nurses' health study II.
Article in Environmental health : a global access science source, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Long-term aircraft noise exposure and risk of hypertension in the Nurses' Health Studies.Environmental research · 2022Pooled it
- Environmental exposures and breast cancer risk in the context of underlying susceptibility: A systematic review of the epidemiological literature.Environmental research · 2020Pooled it
- Residential proximity to national priorities list superfund sites is associated with increased likelihood of metastatic breast cancer presentation.Scientific reports · 2025Article
- Industrial Air Emissions and Breast Cancer Incidence in a United States-wide Prospective Cohort.Epidemiology (Cambridge, Mass.) · 2025Article
- Exposure to Ethylene Oxide and Relative Rates of Female Breast Cancer Mortality: 62 Years of Follow-Up in a Large US Occupational Cohort.Environmental health perspectives · 2025Article
- Heavy-metal associated breast cancer and colorectal cancer hot spots and their demographic and socioeconomic characteristics.Cancer causes & control : CCC · 2024Article
- Carcinogenic industrial air pollution and postmenopausal breast cancer risk in the National Institutes of Health AARP Diet and Health Study.Environment international · 2024Article
- Association of Residential Exposure to Hazardous Air Pollutants with Risk of Non-Hodgkin Lymphoma and Multiple Myeloma.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024Article
- Exposure to outdoor ambient air toxics and risk of breast cancer: The multiethnic cohort.International journal of hygiene and environmental health · 2024Article
- Air quality and cancer risk in the All of Us Research Program.Cancer causes & control : CCC · 2024Article
- Application of the Key Characteristics Framework to Identify Potential Breast Carcinogens Using Publicly AvailableEnvironmental health perspectives · 2024Article
- Research Recommendations for Selected IARC-Classified Agents: Impact and Lessons Learned.Environmental health perspectives · 2023Review
- Associations between long-term aircraft noise exposure, cardiovascular disease, and mortality in US cohorts of female nurses.Environmental epidemiology (Philadelphia, Pa.) · 2023Article
- Ethylene oxide emissions and incident breast cancer and non-Hodgkin lymphoma in a US cohort.Journal of the National Cancer Institute · 2023Article
- Traffic-Related Air Pollution and Breast Cancer Risk: A Systematic Review and Meta-Analysis of Observational Studies.Cancers · 2023Review
- What Geohistory Can Teach Us About Fundamental Causes of Health Inequities.Health equity · 2022Article
- Polycyclic Aromatic Hydrocarbons and Mammary Cancer Risk: Does Obesity Matter too?Journal of cancer immunology · 2021Article
- Outdoor air pollution and cancer: An overview of the current evidence and public health recommendations.CA: a cancer journal for clinicians · 2020Review
- Contribution of socioeconomic and environmental factors to geographic disparities in breast cancer risk in the Nurses' Health Study II.Environmental epidemiology (Philadelphia, Pa.) · 2020Article
- Airborne mammary carcinogens and breast cancer risk in the Sister Study.Environment international · 2019Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundFindings from a recent prospective cohort study in California suggested increased risk of breast cancer associated with higher exposure to certain carcinogenic and estrogen-disrupting hazardous air pollutants (HAPs). However, to date, no nationwide studies have evaluated these possible associations. Our objective was to examine the impacts of mammary carcinogen and estrogen disrupting HAPs on risk of invasive breast cancer in a nationwide cohort.
methodsWe assigned HAPs from the US Environmental Protection Agency's 2002 National Air Toxics Assessment to 109,239 members of the nationwide, prospective Nurses' Health Study II (NHSII). Risk of overall invasive, estrogen receptor (ER)-positive (ER+), and ER-negative (ER-) breast cancer with increasing quartiles of exposure were assessed in time-varying multivariable proportional hazards models, adjusted for traditional breast cancer risk factors.
resultsA total of 3321 invasive cases occurred (2160 ER+, 558 ER-) during follow-up 1989-2011. Overall, there was no consistent pattern of elevated risk of the HAPs with risk of breast cancer. Suggestive elevations were only seen with increasing 1,2-dibromo-3-chloropropane exposures (multivariable adjusted HR of overall breast cancer = 1.12, 95% CI: 0.98-1.29; ER+ breast cancer HR = 1.09; 95% CI: 0.92, 1.30; ER- breast cancer HR = 1.14; 95% CI: 0.81, 1.61; each in the top exposure quartile compared to the lowest).
conclusionsExposures to HAPs during adulthood were not consistently associated with an increased risk of overall or estrogen-receptor subtypes of invasive breast cancer in this nationwide cohort of women.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.