Evidence map›Paper›PMID 29587744›Full record

ArticleBMC veterinary research2018

Safety and efficacy of the mesenchymal stem cell in feline eosinophilic keratitis treatment.

Antonio J Villatoro, Silvia Claros, Viviana Fernández, Cristina Alcoholado, Fernando Fariñas, Antonio Moreno, José Becerra, José A Andrades

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC veterinary research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 45 citations in OpenAlex.

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  19. Effect of allogeneic mesenchymal stem cells (MSCs) on corneal wound healing in dogs.Journal of traditional and complementary medicine · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Antonio J VillatoroImmuneStem, Instituto de Inmunología Clínica y Terapia Celular, 29018, Málaga, Spain.
Silvia ClarosLaboratory of Bioengineering and Tissue Regeneration (LABRET), Department of Cell Biology, Genetics and Physiology, Faculty of Sciences, University of Málaga, Biomedicine Research Institute of Malaga (IBIMA), Campus Universitario de Teatinos, 29071, Málaga, Spain.
Viviana FernándezImmuneStem, Instituto de Inmunología Clínica y Terapia Celular, 29018, Málaga, Spain.
Cristina AlcoholadoLaboratory of Bioengineering and Tissue Regeneration (LABRET), Department of Cell Biology, Genetics and Physiology, Faculty of Sciences, University of Málaga, Biomedicine Research Institute of Malaga (IBIMA), Campus Universitario de Teatinos, 29071, Málaga, Spain.
Fernando FariñasImmuneStem, Instituto de Inmunología Clínica y Terapia Celular, 29018, Málaga, Spain.
Antonio MorenoHospital veterinario Alhaurín el Grande. Alhaurín el Grande, 29120, Málaga, Spain.
José BecerraLaboratory of Bioengineering and Tissue Regeneration (LABRET), Department of Cell Biology, Genetics and Physiology, Faculty of Sciences, University of Málaga, Biomedicine Research Institute of Malaga (IBIMA), Campus Universitario de Teatinos, 29071, Málaga, Spain.
José A AndradesLaboratory of Bioengineering and Tissue Regeneration (LABRET), Department of Cell Biology, Genetics and Physiology, Faculty of Sciences, University of Málaga, Biomedicine Research Institute of Malaga (IBIMA), Campus Universitario de Teatinos, 29071, Málaga, Spain. andrades@uma.es.
Instituto de Investigación Biomédica de Málaga · ESUniversidad de Málaga · ESInmunal (Spain) · ES

Funding

Agencia de Innovación y Desarrollo de Andalucía P11-CVI 07245, PAIDI BIO-217Instituto de Salud Carlos III FIS PI13/00666Ministerio de Ciencia y Tecnología BIO2015-66266-R
6 · The paper itself

Abstract

backgroundFeline eosinophilic keratitis (FEK) is a chronic keratopathy caused by a suspected immune mediated response to an unknown antigenic stimulus. The purpose of this study was to investigate the safety and therapeutic effects of allogeneic feline adipose-derived mesenchymal stromal cells (fAd-MSCs) implanted subconjunctival around the ocular surface lesion in five cats with FEK refractory to current available treatments.

resultsFEK was diagnosed by clinical appearance and evidence of eosinophil and/or mast cells in corneal cytology. Each animal was treated with two applications of 2 × 10

conclusionsImplanted cells were well-tolerated and effective reducing clinical signs of FEK with a sustained effect during the study period. None of the animals showed systemic or local complications during the study. To our knowledge, this is the first time in literature that local implantation of allogeneic fAd-MSCs has been found as an effective therapeutic alternative to treat cats with FEK.

Indexed as

AnimalsCat DiseasesCatsEosinophiliaFemaleKeratitisMaleMesenchymal Stem Cell TransplantationTreatment OutcomeAdipose mesenchymal stem cellAllogeneic cell therapyCatFeline eosinophilic keratitisFeline herpes virusLacrimal gland

Identifiers

PMID29587744
PMCPMC5870249
OpenAlexW2804807049

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.