ArticleBMC veterinary research2018
Isolation, molecular characterization and sero-prevalence study of foot-and-mouth disease virus circulating in central Ethiopia.
Article in BMC veterinary research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Seroprevalence of foot and mouth disease in cattle in East Africa between 2014 and 2024: a systematic review and meta-analysis.BMC veterinary research · 2025Pooled it
- Prioritizing smallholder animal health needs in East Africa, West Africa, and South Asia using three approaches: Literature review, expert workshops, and practitioner surveys.Preventive veterinary medicine · 2021Pooled it
- Seroprevalence and Associated Risk Factors of Foot-and-Mouth Disease in Livestock in Ethiopia: Findings From a National Surveillance (2016-2023).Veterinary medicine and science · 2026Article
- Serotype Characterization and Transmission Modelling of Foot-and-Mouth Disease in Dairy Farms, Bishoftu, Ethiopia.Veterinary medicine and science · 2026Article
- Seroprevalence of foot-and-mouth disease and its association with animal-level and agroecological factors in cattle around Massif Bale Mountain, Ethiopia.BMC veterinary research · 2026Article
- Evolutionary and Spatiotemporal Dynamics of Foot-and-Mouth Disease Virus in Ethiopia (1957-2025): A Molecular Perspective on Serotype Persistence and Emergence.Transboundary and emerging diseases · 2026Review
- Epidemiology of Foot-and-Mouth Disease in Goats in Uganda: A Risk-Based Approach.Transboundary and emerging diseases · 2026Article
- Determinants of Foot and Mouth Virus in Eastern Algeria.Tropical animal health and production · 2025Article
- Sero-Prevalence of Foot-and-Mouth Disease in Cattle in Selected Districts of Jimma Zone, South-Western Ethiopia.Veterinary medicine and science · 2025Article
- MolEpidPred: a novel computational tool for the molecular epidemiology of foot-and-mouth disease virus using VP1 nucleotide sequence data.Briefings in functional genomics · 2025Article
- Serotype Diversity and Molecular Characterization of Foot-and-Mouth Disease Viruses From Outbreaks in Ethiopia (2019-2023): Re-Emergence of SAT 2 After 30 Years.Transboundary and emerging diseases · 2025Article
- Tracing the spread and phylogeography of foot-and-mouth disease virus across East and the Horn of Africa.Virus evolution · 2025Article
- Seroprevalence and serotype distribution of foot and mouth disease virus and associated risk factors in cattle across various export livestock sourcing districts of Bale Zone, Ethiopia.BMC veterinary research · 2024Article
- Seroprevalence and molecular detection of foot and mouth disease virus in cattle in selected districts of Wolaita Zone, Southern Ethiopia.Scientific reports · 2024Article
- A review of foot-and-mouth disease in Ethiopia: epidemiological aspects, economic implications, and control strategies.Virology journal · 2023Review
- Epidemiological study and dairy farmers' knowledge, attitudes, and practices on foot and mouth disease in central Ethiopia.Heliyon · 2023Article
- Epidemiological Dynamics of Foot-and-Mouth Disease in the Horn of Africa: The Role of Virus Diversity and Animal Movement.Viruses · 2023Review
- Combined Adjuvant Formulations Enhanced an Immune Response of Trivalent Foot and Mouth Disease Vaccine in Cattle.Veterinary medicine (Auckland, N.Z.) · 2023Article
- Viral Protein 1 (VP1) Sequence-Based Genetic Diversity of SAT 2 FMDV Circulating in Ethiopia from 1990 to 2015.Veterinary medicine (Auckland, N.Z.) · 2023Article
- Pathological and genetic characterization of foot and mouth disease viruses collected from cattle and water buffalo in Egypt.PloS one · 2023Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEthiopian livestock production and productivity is still very low due to widespread of diseases. Among the diseases, foot-and-mouth disease (FMD) is an extremely contagious and acute viral disease that causes significant economic problems in the country. A cross sectional study design was conducted from September 2015 to May 2016 to isolate and characterize FMD virus from outbreak cases; determine the sero-prevalence of antibodies against FMD virus (FMDV), and assess potential risk factors associated with sero-prevalence of the disease in selected areas of central Ethiopia. A multistage sampling technique was employed to select the study animals. Isolated viruses were characterized by antigen ELISA (IZLER, Brescia, Italy) and by genetic analysis of the sequence of the viral protein 1 (VP1). Sero-prevalence was determined using an ELISA for antibodies against non-structural proteins of FMDV based on the 3ABC proteins (ID Screen® FMD NSP Competition, ID-VET, Grabels, France). Risk factors for sero-prevalence of antibodies against FMD virus was investigated using logistic regression analysis.
resultFrom outbreak investigation, 28.8% (n = 378) cattle showed signs and lesions suggestive of FMD and 34 samples were subjected to virus isolation. Twenty eight of these cultures exhibited cytopathic effect (CPE) and were serotyped as O, A and SAT 2 FMD viruses. One A and two SAT 2 isolates named A-ETH-19-2015, SAT 2-ETH-18-2015 and SAT 2-ETH-20-2015 were further characterized by phylogenetic analysis. The overall sero-prevalence of antibodies against non-structural proteins of FMDV was 24.2% (n = 574). Cattle herds with crossbreed cattle, with older cattle (> 2 years), and kept together with small ruminants had higher sero-prevalences of antibodies against FMDV (p < 0.05).
conclusionThis study showed that FMD was present in the study areas. Among the associated risk factors, breed, age and herd composition were significantly associated with presence of antibodies against FMD virus. Three different serotypes (A, O and SAT 2) were responsible for the outbreaks of the disease. Genetic analysis indicated that the isolated viruses clustered differently from previous outbreaks. Thus, further molecular analyses coupled with protection potential of the existing vaccines against the isolates should be performed.
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