ArticleBMC cancer2018
Shorter survival in adolescent and young adult patients, compared to adult patients, with stage IV colorectal cancer in Japan.
Article in BMC cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 26 citations in OpenAlex.
- Prognosis of early-onset vs. late-onset stage II/III colorectal cancer patients with adjuvant chemotherapy: a multicenter propensity score matched study.International journal of clinical oncology · 2024Article
- Younger patients with colorectal cancer may have better long-term survival after surgery: a retrospective study based on propensity score matching analysis.World journal of surgical oncology · 2024Article
- Article
- The short-term and oncologic outcomes of younger VS older colorectal cancer patients undergoing primary surgery: a propensity score matching analysis.BMC cancer · 2022Article
- Nomogram for predicting overall survival time of patients with stage IV colorectal cancer.Gastroenterology report · 2022Article
- Risks and cancer associations of metachronous and synchronous multiple primary cancers: a 25-year retrospective study.BMC cancer · 2021Article
- Different disease characteristics in young patients with colorectal cancer: a large retrospective study in a city in Romania.The Journal of international medical research · 2021Article
- Clinicopathological Features of Stage I-III Colorectal Cancer Recurrence Over 5 Years After Radical Surgery Without Receiving Neoadjuvant Therapy: Evidence From a Large Sample Study.Frontiers in surgery · 2021Article
- Epidemiology and Outcomes of Young-Onset Esophageal Adenocarcinoma: An Analysis from a Population-Based Database.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021Article
- Prognostic factors of brain metastases from colorectal cancer.BMC cancer · 2019Article
- Early-onset colorectal cancer in young individuals.Molecular oncology · 2019Review
- Clinicogenomic Characteristics and Treatment of Young-Onset Colorectal Cancer Patients Treated With Palliative Therapy in Real-World Practice.Cancer control : journal of the Moffitt Cancer CenterArticle
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9 authors at 1 institution in 1 country.
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Abstract
backgroundThe incidence of colorectal cancer in adolescent and young adult patients is increasing. However, survival and clinical features of young patients, especially those with stage IV disease, relative to adult patients remain unclear.
methodsThis retrospective single-institution cohort study was conducted at a tertiary care cancer center. Subjects were 861 consecutive patients who were diagnosed with stage IV colorectal cancer at the age of 15 to 74 years and who were referred to the division of surgery or gastrointestinal oncology at the National Cancer Center Hospital from 1999 to 2013. Overall survival (OS) was investigated and clinicopathological variables were analyzed for prognostic significance.
resultsOf these, 66 (8%) were adolescent and young adult patients and 795 (92%) were adult patients. Median survival time was 13.6 months in adolescent and young adult patients and 22.4 months in adult patients, and 5-year OS rates were 17.3% and 20.3%, respectively, indicating significant worse prognosis of adolescent and young adult patients (p = 0.042). However, age itself was not an independent factor associated with prognosis by multivariate analysis. When compared with adult patients, adolescent and young adult patients consisted of higher proportion of the patients who did not undergo resection of primary tumor, which was an independent factor associated with poor prognosis in multivariate analysis. In patients who did not undergo resection (n = 349), OS of adolescent and young adult patients were significantly worse (p = 0.033).
conclusionsPrognoses were worse in adolescent and young adult patients with stage IV colorectal cancer compared to adult patients in Japan, due to a higher proportion of patients who did not undergo resection with more advanced and severe disease, but not due to age itself.
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