Evidence map›Paper›PMID 29587682›Full record

ArticleBMC cancer2018

Impact of a behaviorally-based weight loss intervention on parameters of insulin resistance in breast cancer survivors.

Kim L Dittus, Jean R Harvey, Janice Y Bunn, Nathan D Kokinda, Karen M Wilson, Jeff Priest, Richard E Pratley

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01482702 (Impact of Weight Loss Interventions for Overweight Breast Cancer Survivors), which is not on this map. Cited by 16 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 3 pooled it
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01482702 nacompletednot on this map

Impact of Weight Loss Interventions for Overweight Breast Cancer Survivors

TypeinterventionalSponsorUniversity of VermontRan2009 to 2012Enrolled72ConditionsOverweight, Postmenopausal, Breast CancerArmsweight loss intervention, Weight Loss
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Body weight management in overweight and obese breast cancer survivors.The Cochrane database of systematic reviews · 2020
    Pooled it
  4. Trial
  5. Trial
  6. Article
  7. Article
  8. Weight change and diabetes risk following breast cancer: a nationwide cohort study.Journal of cancer survivorship : research and practice · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Observational
  14. Review
  15. Article
  16. Effects of Weight Loss and Weight Regain on Circulating Biomarkers in Overweight/Obese Breast Cancer Survivors Enrolled in a Weight Loss Trial in the Rural Midwest.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Kim L DittusDepartment of Internal Medicine, Vermont Center on Behavior and Health, University of Vermont, Burlington, VT, 05405, USA. kim.dittus@uvmhealth.org.
Jean R HarveyDepartment of Nutrition and Food Sciences, Vermont Center on Behavior and Health, University of Vermont, Burlington, VT, 05405, USA.
Janice Y BunnDepartment of Mathematics and Statistics, University of Vermont, Burlington, VT, 05405, USA.
Nathan D KokindaDepartment of Rehabilitation and Movement Science, University of Vermont, Burlington, VT, 05405, USA.
Karen M WilsonVermont Cancer Center, Burlington, VT, 05405, USA.
Jeff PriestDepartment of Mathematics and Statistics, University of Vermont, Burlington, VT, 05405, USA.
Richard E PratleyFlorida Hospital Translational Research Institute for Metabolism and Diabetes, Sanford Burnham Prebys Medical Discovery Institute, Orlando, FL, 32804, USA.
University of Vermont · USDiscovery Institute · USVermont Cancer Support Network · US

Funding

Vermont Center on Behavior and HealthP20GM103644 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI SIGMON, STACEY C · 2013 to 2022
$21.3M
NIGMS NIH HHS P20 GM103644NIGMS NIH HHS P20GM103644
6 · The paper itself

Abstract

backgroundBreast cancer survivors with excess weight are more likely to have negative breast cancer outcomes. Biomarkers related to insulin resistance may help explain this negative association. Weight loss is associated with improvements in insulin sensitivity. Our goal was to identify the impact of a behaviorally based weight loss intervention on indices of insulin resistance.

methodsOverweight, early stage breast cancer survivors who completed initial cancer therapy were enrolled in a 6 month behaviorally based weight loss intervention that included calorie reduction, exercise and behavior modification. Biomarkers related to insulin resistance were obtained at baseline and after the intervention. Results from participants who achieved ≥5% weight loss were compared to those who lost less weight.

resultsDespite not having diabetes as a preexisting diagnosis prior to the study, 69% of all participants were considered to have pre-diabetes or diabetes at baseline based on American Diabetes Association definitions. Participants who achieved ≥5% weight loss had significantly lower fasting insulin, AUC insulin, and insulin resistance as measured by HOMA-IR. Beta cell function decreased as anticipated when insulin resistance improved. Additionally, leptin levels declined.

conclusionsBreast cancer survivors who achieved ≥5% weight loss demonstrated significant improvements in indices of insulin resistance. Despite an exclusion criteria of diabetes at the time of enrolment, a high proportion met criteria for pre-diabetes or diabetes at baseline. Pre-diabetes appears to be under recognized in overweight breast cancer survivors. Behaviorally based weight loss interventions can result in weight loss and improvements in biomarkers related to breast cancer outcomes and additionally may decrease the chance of developing diabetes.

trial registrationNCT01482702 4/12/2010 (retrospectively registered).  https://clinicaltrials.gov/ct2/show/NCT01482702?term=Dittus&rank=4.

Indexed as

Behavior ControlCancer SurvivorsInsulin ResistanceWeight LossAdultBiomarkersBreast NeoplasmsCombined Modality TherapyFemaleHumansMiddle AgedNeoplasm StagingQuality of LifeBiomarkersBiomarkerBreast cancerWeight loss

Identifiers

PMID29587682
PMCPMC5872579
OpenAlexW2803105771

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.