Evidence map›Paper›PMID 29587672›Full record

Observational studyBMC psychiatry2018

Characteristics of patients with depression initiating or switching antidepressant treatment: baseline analyses of the PERFORM cohort study.

Josep Maria Haro, François-Xavier Lamy, Bengt Jönsson, Martin Knapp, Mélanie Brignone, Hugo Caillou, Ylana Chalem, Lene Hammer-Helmich, Benoît Rive, Delphine Saragoussi

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01427439 (A Prospective Epidemiological Research on Functioning Outcomes Related to Major Depressive Disorder), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01427439 completednot on this map

A Prospective Epidemiological Research on Functioning Outcomes Related to Major Depressive Disorder

TypeobservationalSponsorH. Lundbeck A/SRan2011Enrolled1,455ConditionsMajor Depressive Disorder
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Josep Maria HaroParc Sanitari Sant Joan de Deu, Universitat de Barcelona, CIBERSAM, C/ Doctor Antoni Pujadas 42, 08830 Sant Boi de Llobregat, Barcelona, Spain.
François-Xavier LamyLundbeck SAS, 37-45 Quai du Président Roosevelt, 92445, Issy-les-Moulineaux, France.
Bengt JönssonDepartment of Economics, Stockholm School of Economics, Sveavägen 65, 113 83, Stockholm, Sweden.
Martin KnappPersonal Social Services Research Unit, Cowdray House, London School of Economics and Political Science, Houghton Street, London, WC2A 2AE, UK.
Mélanie BrignoneLundbeck SAS, 37-45 Quai du Président Roosevelt, 92445, Issy-les-Moulineaux, France.
Hugo CaillouInferential, 35 rue Godot de Mauroy, 75009, Paris, France.
Ylana ChalemLundbeck SAS, 37-45 Quai du Président Roosevelt, 92445, Issy-les-Moulineaux, France.
Lene Hammer-HelmichH. Lundbeck A/S, Ottiliavej 9, 2500, Valby, Denmark. LEEM@lundbeck.com.
Benoît RiveLundbeck SAS, 37-45 Quai du Président Roosevelt, 92445, Issy-les-Moulineaux, France.
Delphine SaragoussiLundbeck SAS, 37-45 Quai du Président Roosevelt, 92445, Issy-les-Moulineaux, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients who require a switch in their antidepressant therapy may have different clinical profiles and treatment needs compared with patients initiating or maintaining a first-line antidepressant therapy.

methodsThe Prospective Epidemiological Research on Functioning Outcomes Related to Major depressive disorder (MDD) (PERFORM) study was a 2-year observational cohort study in outpatients with MDD in five European countries. Enrolled patients were either initiating or undergoing the first switch to an antidepressant monotherapy. Baseline data on patients' clinical status, functioning, productivity, quality of life and medical-resource use were compared in a cross-sectional baseline analysis.

resultsA total of 1402 patients were enrolled, of whom 1159 (82.7%) provided analysable baseline data. The majority (78.7%) of the analysable population were initiating antidepressant treatment and most (83.6%) were enrolled and followed up by general practitioners. Compared with patients initiating antidepressants, those switching antidepressants (21.3%) tended to have more severe depressive symptoms, greater anxiety, worse health-related quality of life, greater functional impairment, greater medical-resource use and had a different medical history. Limitations included an over-representation of switches due to lack of efficacy among patients who were switching treatment, as patients were selected based on presence of depressive symptoms.

conclusionsPatients with MDD who are switching treatment for the first time have a different profile and different depression-associated health needs compared with those initiating treatment. Therapeutic management should therefore be adapted for patients who switch.

trial registrationClinicalTrials.gov NCT01427439 ; Retrospectively registered 26 August 2011.

Indexed as

Drug-Seeking BehaviorDrug SubstitutionAdultAntidepressive AgentsAnxietyCross-Sectional StudiesDepressionEuropeFemaleHumansMajor Depressive DisorderMaleMiddle AgedProspective StudiesQuality of LifeAntidepressive AgentsBaseline surveyDepressionDrug switchingObservational study

Identifiers

PMID29587672
PMCPMC5870247

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.