Evidence map›Paper›PMID 29587364›Full record

ArticleInternational journal of molecular sciences2018

Baicalein Rescues Delayed Cooling via Preservation of Akt Activation and Akt-Mediated Phospholamban Phosphorylation.

Zuohui Shao, Sy-Jou Chen, Xiangdong Zhu, Chunpei Lee, Hsien-Hao Huang, Angelo Meliton, Changqing Li, Terry L Vanden Hoek, Jing Li

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Zuohui ShaoCenter of Advanced Resuscitation Medicine, Center for Cardiovascular Research, Department of Emergency Medicine, University of Illinois Hospital, and Health Sciences System, Chicago, IL 60612, USA. zshao42@gmail.com.
Sy-Jou ChenCenter of Advanced Resuscitation Medicine, Center for Cardiovascular Research, Department of Emergency Medicine, University of Illinois Hospital, and Health Sciences System, Chicago, IL 60612, USA. syjou.chen@mail.ndmctsgh.edu.tw.
Xiangdong ZhuCenter of Advanced Resuscitation Medicine, Center for Cardiovascular Research, Department of Emergency Medicine, University of Illinois Hospital, and Health Sciences System, Chicago, IL 60612, USA. xiangdon@uic.edu.
Chunpei LeeCenter of Advanced Resuscitation Medicine, Center for Cardiovascular Research, Department of Emergency Medicine, University of Illinois Hospital, and Health Sciences System, Chicago, IL 60612, USA. pheanys@uic.edu.
Hsien-Hao HuangCenter of Advanced Resuscitation Medicine, Center for Cardiovascular Research, Department of Emergency Medicine, University of Illinois Hospital, and Health Sciences System, Chicago, IL 60612, USA. hhhuang@vghtpe.gov.tw.
Angelo MelitonDepartment of Medicine, Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, IL 60637, USA. ameliton@uchicago.edu.
Changqing LiCenter of Advanced Resuscitation Medicine, Center for Cardiovascular Research, Department of Emergency Medicine, University of Illinois Hospital, and Health Sciences System, Chicago, IL 60612, USA. cqli41s@gmail.com.
Terry L Vanden HoekCenter of Advanced Resuscitation Medicine, Center for Cardiovascular Research, Department of Emergency Medicine, University of Illinois Hospital, and Health Sciences System, Chicago, IL 60612, USA. tvh@uic.edu.
Jing LiCenter of Advanced Resuscitation Medicine, Center for Cardiovascular Research, Department of Emergency Medicine, University of Illinois Hospital, and Health Sciences System, Chicago, IL 60612, USA. jingli92@uic.edu.
University of Illinois Chicago · USUniversity of Illinois Hospital & Health Sciences System · USNational Yang Ming Chiao Tung University · TWUniversity of Chicago · US

Funding

Novel Therapies for CPRR01GM120485 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI O'DONNELL, J. MICHAEL, VANDEN HOEK, TERRY L. · 2017 to 2020
$1.2M
HERB-INDUCED OXIDANT PRECONDITIONING IN CARDIOMYOCYTESR21AT003441 · NCCIH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI SHAO, ZUO-HUI · 2009 to 2010
$427k
NCCIH NIH HHS R21 AT003441NIGMS NIH HHS R01 GM120485
6 · The paper itself

Abstract

Cooling reduces the ischemia/reperfusion (I/R) injury seen in sudden cardiac arrest (SCA) by decreasing the burst of reactive oxygen species (ROS). Its cardioprotection is diminished when delay in reaching the target temperature occurs. Baicalein, a flavonoid derived from the root of

Indexed as

AnimalsAntioxidantsCalcium-Binding ProteinsCardiotonic AgentsCell SurvivalCold TemperatureFlavanonesMiceMice, Inbred C57BLMyocardial ContractionMyocardial Reperfusion InjuryMyocardial StunningMyocytes, CardiacPhospholambanPhosphorylationPrimary Cell CultureAntioxidantsbaicaleinCalcium-Binding ProteinsCardiotonic AgentsFlavanonesPhospholambanProto-Oncogene Proteins c-aktReactive Oxygen SpeciesAktbaicaleincardiomyocytecell deathcontractilitydelayed coolingintraischemic coolingischemia/reperfusionreactive oxygen species (ROS)

Identifiers

PMID29587364
PMCPMC5979521
OpenAlexW2790316402

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.