ArticleEpidemiology and health2018
Interpretation of the hygiene and microflora hypothesis for allergic diseases through epigenetic epidemiology.
Article in Epidemiology and health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed.
- Life-course hygiene exposures and disorders of gut-brain interaction: a multinational cross-sectional study.Internal and emergency medicine · 2026Article
- Causal relationship between gut microbiome and childhood allergy: A bidirectional Mendelian randomization analysis.Medicine · 2026Article
- Multicenter study of seasonal and regional airborne allergens in Chinese preschoolers with allergic rhinitis.Scientific reports · 2024Article
- Pathogenesis of Children's Allergic Diseases: Refocusing the Role of the Gut Microbiota.Frontiers in physiology · 2021Review
- Eradication ofFrontiers in microbiology · 2021Review
- Blockade of enhancer of zeste homolog 2 alleviates renal injury associated with hyperuricemia.American journal of physiology. Renal physiology · 2019Article
- Necessity of Epigenetic Epidemiology Studies on the Carcinogenesis of Lung Cancer in Never Smokers.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2018Article
- Researches of Epigenetic Epidemiology for Infections and Radiation as Carcinogen.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2018Review
Corrections and comments
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Authors and funding
1 author.
Funding
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Abstract
The hygiene hypothesis (HH) proposed by Strachan in 1989 was expanded to explain the inverse association between the occurrence of allergy disorders and the risk of infectious diseases and parasite infestation. The microflora hypothesis (MH) suggests that gut microbial dysbiosis in early life might trigger hypersensitivity disorders. The sharing concept of both HH and MH is gene-environment interaction, which is also a key concept in epigenetics. The amalgamation of epidemiology and epigenetics has created a scientific discipline termed epigenetic epidemiology. To accomplish an era of gene-environment-wide interaction studies, it is necessary to launch a national human epigenome project.
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Registered trials
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