Evidence map›Paper›PMID 29587139›Full record

ArticleDevelopmental cell2018

Quality before Quantity: Inspecting CFTR.

Hongmei Mou

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Developmental cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Hongmei MouThe Mucosal Immunology and Biology Research Center, Massachusetts General Hospital, Jackson 1402, 55 Fruit Street, Boston, MA 02114, USA; Massachusetts General Hospital for Children, Pediatric Pulmonary Medicine, Boston, MA, USA. Electronic address: hmou@mgh.harvard.edu.
Boston Children's Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CFTR biosynthesis is highly dynamic. In this issue of Developmental Cell, Okiyoneda et al. (2018) show that RFFL serves as a CFTR conformation scrutinizer at the plasma membrane. It recognizes misfolded CFTR proteins and marks them for degradation. This quality control mechanism may be explored to benefit cystic fibrosis patients.

Indexed as

Cystic Fibrosis Transmembrane Conductance RegulatorProtein FoldingCell MembraneCystic FibrosisHumansCystic Fibrosis Transmembrane Conductance Regulator

Identifiers

PMID29587139
OpenAlexW2794829327

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.