ArticleOtolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery2018
Direct Analysis of Pathogenic Structures Affixed to the Tympanic Membrane during Chronic Otitis Media.
Article in Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Enhanced Eustachian Tube Function and Hearing Recovery with Combined Balloon Dilatation and Tympanic Membrane Catheterization in Secretory Otitis Media.Medical science monitor : international medical journal of experimental and clinical research · 2025Trial
- Artificial Intelligence in Label-Free Optical Imaging Applications.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Texture-based speciation of otitis media-related bacterial biofilms from optical coherence tomography images using supervised classification.Journal of biophotonics · 2024Article
- In Vivo Optical Characterization of Middle Ear Effusions and Biofilms During Otitis Media.Journal of the Association for Research in Otolaryngology : JARO · 2023Observational
- Automated classification of otitis media with OCT: augmenting pediatric image datasets with gold-standard animal model data.Biomedical optics express · 2022Article
- Multimodal Handheld Probe for Characterizing Otitis Media - Integrating Raman Spectroscopy and Optical Coherence Tomography.Frontiers in photonics · 2022Article
- In vivo functional imaging of the human middle ear with a hand-held optical coherence tomography device.Biomedical optics express · 2021Article
- Inactivation and sensitization of Pseudomonas aeruginosa by microplasma jet array for treating otitis media.NPJ biofilms and microbiomes · 2021Article
- Handheld Briefcase Optical Coherence Tomography with Real-Time Machine Learning Classifier for Middle Ear Infections.Biosensors · 2021Article
- In vivo dynamic characterization of the human tympanic membrane using pneumatic optical coherence tomography.Journal of biophotonics · 2021Article
- Longitudinal optical coherence tomography to visualize the in vivo response of middle ear biofilms to antibiotic therapy.Scientific reports · 2021Article
- A bench-top model of middle ear effusion diagnosed with optical tympanometry.International journal of pediatric otorhinolaryngology · 2020Article
- Otitis Media Middle Ear Effusion Identification and Characterization Using an Optical Coherence Tomography Otoscope.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2020Article
- Panel 8: Vaccines and immunology.International journal of pediatric otorhinolaryngology · 2020Review
- Panel 1: Biotechnology, biomedical engineering and new models of otitis media.International journal of pediatric otorhinolaryngology · 2020Review
- Antibiotic modulation of mucins in otitis media; should this change our approach to watchful waiting?International journal of pediatric otorhinolaryngology · 2019Article
- In vivo detection of endotracheal tube biofilms in intubated critical care patients using catheter-based optical coherence tomography.Journal of biophotonics · 2019Article
- Automated classification platform for the identification of otitis media using optical coherence tomography.NPJ digital medicine · 2019Article
- Economical and compact briefcase spectral-domain optical coherence tomography system for primary care and point-of-care applications.Journal of biomedical optics · 2018Article
- Assessing the Effect of Middle Ear Effusions on Wideband Acoustic Immittance Using Optical Coherence Tomography.Ear and hearingArticle
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Objective To characterize otitis media-associated structures affixed to the mucosal surface of the tympanic membrane (TM) in vivo and in surgically recovered in vitro samples. Study Design Prospective case series without comparison. Setting Outpatient surgical care center. Subjects and Methods Forty pediatric subjects scheduled for tympanostomy tube placement surgery were imaged intraoperatively under general anesthesia. Postmyringotomy, a portable optical coherence tomography (OCT) imaging system assessed for the presence of any biofilm affixed to the mucosal surface of the TM. Samples of suspected microbial infection-related structures were collected through the myringotomy incision. The sampled site was subsequently reimaged with OCT to confirm collection from the original image site on the TM. In vitro analysis based on confocal laser scanning microscope (CLSM) images of fluorescence in situ hybridization-tagged samples and polymerase chain reaction (PCR) provided microbiological characterization and verification of biofilm activity. Results OCT imaging was achieved for 38 of 40 subjects (95%). Images from 38 of 38 (100%) of subjects observed with OCT showed the presence of additional microbial infection-related structures. Thirty-four samples were collected from these 38 subjects. CLSM images provided evidence of clustered bacteria in 32 of 33 (97%) of samples. PCR detected the presence of active bacterial DNA signatures in 20 of 31 (65%) of samples. Conclusion PCR and CLSM analysis of fluorescence in situ hybridization-stained samples validates the presence of active bacteria that have formed into a middle ear biofilm that extends across the mucosal layer of the TM. OCT can rapidly and noninvasively identify middle ear biofilms in subjects with severe and persistent cases of otitis media.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.