Evidence map›Paper›PMID 29587047›Full record

ArticleMedical decision making : an international journal of the Society for Medical Decision Making2018

Microsimulation Modeling for Health Decision Sciences Using R: A Tutorial.

Eline M Krijkamp, Fernando Alarid-Escudero, Eva A Enns, Hawre J Jalal, M G Myriam Hunink, Petros Pechlivanoglou

Open access · greenAbstract readComparative Study
In one paragraph

Article in Medical decision making : an international journal of the Society for Medical Decision Making, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed, 2 pooled it
10.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

101 citing papers in PubMed, 2 syntheses or guidelines pooled it, 172 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Distributional Cost-Effectiveness Analysis Using Microsimulation in R: A Tutorial.Medical decision making : an international journal of the Society for Medical Decision Making · 2026
    Article
  5. Article
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  8. A Tutorial on Discrete Event Simulation Models Using a Cost-Effectiveness Analysis Example in R.Medical decision making : an international journal of the Society for Medical Decision Making · 2026
    Article
  9. Article
  10. A Novel Decision-Modeling Framework for Health Policy Analyses When Outcomes Are Influenced by Social and Disease Processes.Medical decision making : an international journal of the Society for Medical Decision Making · 2026
    Article
  11. Cost-Effectiveness of First-Line Immunochemotherapy VersusCurrent oncology (Toronto, Ont.) · 2026
    Article
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41 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Eline M KrijkampErasmus MC, Epidemiology Department, Rotterdam, The Netherlands.
Fernando Alarid-EscuderoUniversity of Minnesota School of Public Health, Minneapolis, MN, USA.
Eva A EnnsUniversity of Minnesota School of Public Health, Minneapolis, MN, USA.
Hawre J JalalUniversity of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA.
M G Myriam HuninkErasmus MC, Epidemiology Department, Rotterdam, The Netherlands.
Petros PechlivanoglouChild Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada.
Erasmus University Rotterdam · NLUniversity of Minnesota · USHospital for Sick Children · CAUniversity of Pittsburgh · US

Funding

Comparative Modeling of Colorectal Cancer: Informing Health Policies and Prioritizing Future ResearchU01CA199335 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI KUNTZ, KAREN M, LANSDORP-VOGELAAR, IRIS · 2015 to 2019
$5.5M
Mathematical modeling and analysis of HIV care trajectories and retention in care challengesK25AI118476 · NIAID · UNIVERSITY OF MINNESOTA · PI ENNS, EVA A · 2015 to 2019
$649k
NCI NIH HHS U01 CA199335NIAID NIH HHS K25 AI118476
6 · The paper itself

Abstract

Microsimulation models are becoming increasingly common in the field of decision modeling for health. Because microsimulation models are computationally more demanding than traditional Markov cohort models, the use of computer programming languages in their development has become more common. R is a programming language that has gained recognition within the field of decision modeling. It has the capacity to perform microsimulation models more efficiently than software commonly used for decision modeling, incorporate statistical analyses within decision models, and produce more transparent models and reproducible results. However, no clear guidance for the implementation of microsimulation models in R exists. In this tutorial, we provide a step-by-step guide to build microsimulation models in R and illustrate the use of this guide on a simple, but transferable, hypothetical decision problem. We guide the reader through the necessary steps and provide generic R code that is flexible and can be adapted for other models. We also show how this code can be extended to address more complex model structures and provide an efficient microsimulation approach that relies on vectorization solutions.

Indexed as

Decision Support Systems, ClinicalProgramming LanguagesAlgorithmsClinical Decision-MakingCohort StudiesComputer SimulationCost-Benefit AnalysisHumansMarkov ChainsQuality-Adjusted Life YearsQuality of LifeSeverity of Illness IndexSoftwaredecision-analytic modelingMarkov modelmicrosimulationopen source softwareR project

Identifiers

PMID29587047
PMCPMC6349385
OpenAlexW2795262817

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.