ArticleJournal of radiation research2018
National survey of myeloablative total body irradiation prior to hematopoietic stem cell transplantation in Japan: survey of the Japanese Radiation Oncology Study Group (JROSG).
Article in Journal of radiation research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 24 citations in OpenAlex.
- Preclinical feasibility of EPID-based transit dosimetry for total body irradiation.Journal of applied clinical medical physics · 2026Article
- Large-field irradiation techniques in Germany: A DGMP Working Group survey on the current clinical implementation of total body irradiation, total skin irradiation and craniospinal irradiation.Zeitschrift fur medizinische Physik · 2026Article
- Effect of conditioning intensity on late complications in AYA who underwent allogeneic HCT during childhood.International journal of hematology · 2025Article
- A multi-institutional survey on technical variations in total body irradiation in Japan.Radiological physics and technology · 2025Article
- Article
- Commissioning and performance evaluation of commercially available mobile imager for image guided total body irradiation.Journal of applied clinical medical physics · 2023Article
- Optimised conformal total body irradiation: a heterogeneous practice, so where next?The British journal of radiology · 2023Review
- New strategy of a lung compensating technique with STR for total body irradiation.Journal of applied clinical medical physics · 2022Article
- Two compound techniques for total body irradiation.Technical innovations & patient support in radiation oncology · 2022Article
- Feasibility study of volumetric modulated arc therapy with Halcyon™ linac for total body irradiation.Radiation oncology (London, England) · 2021Article
- Total Body Irradiation in Haematopoietic Stem Cell Transplantation for Paediatric Acute Lymphoblastic Leukaemia: Review of the Literature and Future Directions.Frontiers in pediatrics · 2021Review
- The safety and efficacy of a novel hypo-fractionated total marrow and lymphoid irradiation before allogeneic stem cell transplantation for lymphoma and acute leukemia.Clinical and translational radiation oncology · 2021Article
- Commissioning of total body irradiation using plastic bead bags.Journal of radiation research · 2020Article
- Standardized flattening filter free volumetric modulated arc therapy plans based on anteroposterior width for total body irradiation.Journal of applied clinical medical physics · 2020Article
- National survey on total-body irradiation prior to reduced-intensity stem cell transplantation in Japan: The Japanese Radiation Oncology Study Group.Journal of radiation research · 2019Article
- Clinical significance of low-dose total body irradiation in HLA-mismatched reduced-intensity stem cell transplantation.Bone marrow transplantation · 2019Article
- Total Body Irradiation and Total Skin Irradiation Techniques in Belgium and the Netherlands: Current Clinical Practice.Advances in radiation oncologyArticle
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Authors and funding
16 authors at 12 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A myeloablative regimen that includes total-body irradiation (TBI) before hematopoietic stem cell transplantation results in higher patient survival rates than achieved with regimens without TBI. The TBI protocol, however, varies between institutions. In October 2015, the Japanese Radiation Oncology Study Group initiated a national survey of myeloablative TBI (covering 2010-2014). Among the 186 Japanese institutions performing TBI, 90 (48%) responded. The 82 institutions that had performed myeloablative TBI during this period treated 2698 patients with malignant disease [leukemia (2082 patients, 77.2%), malignant lymphoma (378, 14%)] and 37 with non-malignant disease [severe aplastic anemia (20, 54%), inborn errors of metabolism (5, 14%)]. A linear accelerator was used at all institutions. The institutions were divided into 41 large and 41 small institutions based on the median number of patients. The long source-surface distance technique was the method of choice in the 34 institutions (82.9%) and the moving-couch technique in the 7 (17.1%) in the large institutions. The schedules most routinely used by the participating institutions consisted of 12 Gy/6 fractions/3 days (26 institutions, 63.5%) in the large institutions. The dose rate varied from 5 to 26 cGy/min. The lungs and lenses were routinely shielded in 23 large institutions (56.1%), and only the lungs in 9 large institutions (21.9%). At lung-shielding institutions, the most frequent maximum acceptable total dose for the lungs was 8 Gy (19 institutions, 27.5%). Our results reveal considerable differences in the TBI methods used by Japanese institutions and thus the challenges in designing multicenter randomized trials based on TBI.
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