Evidence map›Paper›PMID 29584652›Full record

ArticleViruses2018

Identification of Ellagic Acid from Plant Rhodiola rosea L. as an Anti-Ebola Virus Entry Inhibitor.

Qinghua Cui, Ruikun Du, Manu Anantpadma, Adam Schafer, Lin Hou, Jingzhen Tian, Robert A Davey, Han Cheng, Lijun Rong

Abstract read
In one paragraph

Article in Viruses, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
  6. Inhibition of Monkeypox Virus DNA Polymerase UsingIndian journal of microbiology · 2024
    Article
  7. In Vitro Antiviral Activity ofPharmaceuticals (Basel, Switzerland) · 2024
    Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Ebola Entry Inhibitors Discovered fromInternational journal of molecular sciences · 2022
    Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Qinghua CuiCollege of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China. user753951@163.com.
Ruikun DuCollege of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China. ruikun7128@gmail.com.
Manu AnantpadmaDepartment of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, TX 78227, USA. manantpadma@txbiomed.org.
Adam SchaferDepartment of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA. aschaf5@uic.edu.
Lin HouCollege of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China. houlin5027@163.com.
Jingzhen TianCollege of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China. tianjingzhen@163.com.
Robert A DaveyDepartment of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, TX 78227, USA. rdavey@txbiomed.org.ORCID 0000-0001-9168-2892
Han ChengDepartment of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA. hancheng@uic.edu.
Lijun RongDepartment of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA. lijun@uic.edu.

Funding

Novel broad spectrum inhibitors of filovirus infectionR21AI115082 · NIAID · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI DAVEY, ROBERT A · 2015 to 2016
$509k
NIAID NIH HHS R21 AI115082
6 · The paper itself

Abstract

The recent 2014-2016 West African Ebola virus epidemic underscores the need for the development of novel anti-Ebola therapeutics, due to the high mortality rates of Ebola virus infections and the lack of FDA-approved vaccine or therapy that is available for the prevention and treatment. Traditional Chinese medicines (TCMs) represent a huge reservoir of bioactive chemicals and many TCMs have been shown to have antiviral activities. 373 extracts from 128 TCMs were evaluated using a high throughput assay to screen for inhibitors of Ebola virus cell entry. Extract of

Indexed as

A549 CellsAntiviral AgentsCell LineCell SurvivalEbolavirusEllagic AcidGallic AcidHeLa CellsHemorrhagic Fever, EbolaHigh-Throughput Screening AssaysHumansInhibitory Concentration 50MarburgvirusMedicine, Chinese TraditionalPlant ExtractsRhodiolaAntiviral AgentsEllagic AcidGallic AcidPlant ExtractsEbolaellagic acidgallic acidMarburgRhodiola roseaTraditional Chinese medicine

Identifiers

PMID29584652
PMCPMC5923446

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.