ArticleSensors (Basel, Switzerland)2018
Electronic Detection of DNA Hybridization by Coupling Organic Field-Effect Transistor-Based Sensors and Hairpin-Shaped Probes.
Article in Sensors (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Boron-doped diamond solution-gate field-effect transistor (BDD-SGFET) biosensor for gene mutation detection.Microsystems & nanoengineering · 2026Article
- Organic Bioelectronics Development in Italy: A Review.Micromachines · 2023Review
- Nucleotide detection mechanism and comparison based on low-dimensional materials: A review.Frontiers in bioengineering and biotechnology · 2023Review
- Simultaneous recording of electrical and metabolic activity of cardiac cellsFrontiers in bioengineering and biotechnology · 2022Article
- Electronic Sensing Platform (ESP) Based on Open-Gate Junction Field-Effect Transistor (OG-JFET) for Life Science Applications: Design, Modeling and Experimental Results.Sensors (Basel, Switzerland) · 2021Article
- Bio-Separated and Gate-Free 2D MoSNanomaterials (Basel, Switzerland) · 2021Article
- Electrolyte-gated transistors for enhanced performance bioelectronics.Nature reviews. Methods primers · 2021Article
- Field-Effect Transistor Biosensors for Biomedical Applications: Recent Advances and Future Prospects.Sensors (Basel, Switzerland) · 2019Review
- An organic neurophysiological tool for neuronal metabolic activity monitoring.APL bioengineering · 2018Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this paper, the electronic transduction of DNA hybridization is presented by coupling organic charge-modulated field-effect transistors (OCMFETs) and hairpin-shaped probes. These probes have shown interesting properties in terms of sensitivity and selectivity in other kinds of assays, in the form of molecular beacons (MBs). Their integration with organic-transistor based sensors, never explored before, paves the way to a new class of low-cost, easy-to-use, and portable genetic sensors with enhanced performances. Thanks to the peculiar characteristics of the employed sensor, measurements can be performed at relatively high ionic strengths, thus optimizing the probes' functionality without affecting the detection ability of the device. A complete electrical characterization of the sensor is reported, including calibration with different target concentrations in the measurement environment and selectivity evaluation. In particular, DNA hybridization detection for target concentration as low as 100 pM is demonstrated.
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Registered trials
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