ArticleAsian Pacific journal of cancer prevention : APJCP2018
Nasopharyngeal Carcinoma Protein Interaction Mapping Analysis via Proteomic Approaches
Article in Asian Pacific journal of cancer prevention : APJCP, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- The Roles of the PRDM Family in the Neuro-Motor System.Biomolecules · 2026Review
- Article
- Integrated analysis of single-cell and bulk RNA-sequencing reveals tumor heterogeneity and a signature based on NK cell marker genes for predicting prognosis in hepatocellular carcinoma.Frontiers in pharmacology · 2023Article
- Pathogenesis and prognosis of primary oral squamous cell carcinoma based on microRNAs target genes: a systems biology approach.Genomics & informatics · 2022Article
- Current Status and Future Perspectives about Molecular Biomarkers of Nasopharyngeal Carcinoma.Cancers · 2021Review
- Research status and prospects of biomarkers for nasopharyngeal carcinoma in the era of high‑throughput omics (Review).International journal of oncology · 2021Review
- Investigation of PRDM10 and PRDM13 Expression in Developing Mouse Embryos by an Optimized PACT-Based Embryo Clearing Method.International journal of molecular sciences · 2021Article
- CALM1 promotes progression and dampens chemosensitivity to EGFR inhibitor in esophageal squamous cell carcinoma.Cancer cell international · 2021Article
- In-Silico Multi-Omics Analysis of the Functional Significance of Calmodulin 1 in Multiple Cancers.Frontiers in genetics · 2021Article
- Multifaceted Role of PRDM Proteins in Human Cancer.International journal of molecular sciences · 2020Review
- Identification of chemoresistance-associated miRNAs in breast cancer.Cancer management and research · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nasopharyngeal carcinoma (NPC), although not very common in many parts of the world, is a major concern in some countries, including Iran. Molecular studies are very helpful to provide essential information regarding underlying carcinogenetic mechanisms. Here, considering NPC proteomic approaches, established biomarkers were designated for protein-protein interaction network construction and analysis with corresponding plug-ins. A network of reported protein markers was constructed and topological and biological process features were investigated. Centrality analysis showed that JUN, CALM1, HSB1, and SOD1 are more important than other differentially expressed proteins in an interacting pattern. What is more, by extending the network, Tp53, PRDM10, AKT1, ALB, HSP90AA1, and EGFR achieved the highest values for NPC network strength. It can be concluded that these proteins as well as their contributing processes, particularly in a second network, may be important for NPC onset and development. Targeting these candidate proteins may allow novel treatment approaches following appropriate validation.
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