ArticleHuman brain mapping2018
Reproducibility of myelin content-based human habenula segmentation at 3 Tesla.
Article in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- The habenula in mood disorders: A systematic review of human studies.Molecular psychiatry · 2025Pooled it
- Significant heterogeneity in structural asymmetry of the habenula in the human brain: A systematic review and meta-analysis.Human brain mapping · 2023Pooled it
- Reproducibility of automated habenula segmentation via deep learning in major depressive disorder and normal controls with 7 Tesla MRI.Scientific reports · 2021Trial
- Habenula volume alterations in adults born very preterm.Scientific reports · 2026Article
- Fifteen years on: a review of the Cam-CAN study of the cognitive neuroscience of ageing.GeroScience · 2026Review
- Altered volumetric and functional connectivity of the habenula in chronic insomnia disorder.Frontiers in neuroscience · 2026Article
- Segmentation and Volume Estimation of the Habenula Using Deep Learning in Patients With Depression.Biological psychiatry global open science · 2024Article
- Visualizing the Habenula Using 3T High-Resolution MP2RAGE and QSM: A Preliminary Study.AJNR. American journal of neuroradiology · 2024Article
- Altered habenular connectivity in chronic low back pain: An fMRI and machine learning study.Human brain mapping · 2023Article
- Abnormal functional connectivity in the habenula is associated with subjective hyperarousal state in chronic insomnia disorder.Frontiers in neurology · 2023Article
- High-resolution Structural Magnetic Resonance Imaging and Quantitative Susceptibility Mapping.Magnetic resonance imaging clinics of North America · 2021Review
- Multimodal Investigations of Reward Circuitry and Anhedonia in Adolescent Depression.Frontiers in psychiatry · 2021Review
- Article
- Reproducibility of myelin content-based human habenula segmentation at 3 Tesla.Human brain mapping · 2018Article
- Imaging Habenula Volume in Schizophrenia and Bipolar Disorder.Frontiers in psychiatry · 2018Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
Abstract
In vivo morphological study of the human habenula, a pair of small epithalamic nuclei adjacent to the dorsomedial thalamus, has recently gained significant interest for its role in reward and aversion processing. However, segmenting the habenula from in vivo magnetic resonance imaging (MRI) is challenging due to the habenula's small size and low anatomical contrast. Although manual and semi-automated habenula segmentation methods have been reported, the test-retest reproducibility of the segmented habenula volume and the consistency of the boundaries of habenula segmentation have not been investigated. In this study, we evaluated the intra- and inter-site reproducibility of in vivo human habenula segmentation from 3T MRI (0.7-0.8 mm isotropic resolution) using our previously proposed semi-automated myelin contrast-based method and its fully-automated version, as well as a previously published manual geometry-based method. The habenula segmentation using our semi-automated method showed consistent boundary definition (high Dice coefficient, low mean distance, and moderate Hausdorff distance) and reproducible volume measurement (low coefficient of variation). Furthermore, the habenula boundary in our semi-automated segmentation from 3T MRI agreed well with that in the manual segmentation from 7T MRI (0.5 mm isotropic resolution) of the same subjects. Overall, our proposed semi-automated habenula segmentation showed reliable and reproducible habenula localization, while its fully-automated version offers an efficient way for large sample analysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.