Evidence map›Paper›PMID 29582464›Full record

ArticleMagnetic resonance in medicine2018

Super-resolution musculoskeletal MRI using deep learning.

Akshay S Chaudhari, Zhongnan Fang, Feliks Kogan, Jeff Wood, Kathryn J Stevens, Eric K Gibbons, Jin Hyung Lee, Garry E Gold, Brian A Hargreaves

Registry-linked trialAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05820113 (Deep Learning Super Resolution Reconstruction for Fast and Motion Robust T2-weighted Prostate MRI), which is not on this map. Cited by 143 papers.

0numbers the graph read from it
0cells of the map it votes in
143citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05820113 nacompletednot on this mapstarted 2022, after this paper: background citation

Deep Learning Super Resolution Reconstruction for Fast and Motion Robust T2-weighted Prostate MRI

TypeinterventionalSponsorUniversity Hospital, BonnRan2022 to 2022Enrolled109ConditionsProstate Cancer, Multiparametric MRIArmsDeep learning based reconstruction of T2-TSE sequence
3 · Its place in the literature

Who cites it

143 citing papers in PubMed.

  1. Article
  2. Article
  3. Application of Deep Learning-Based Reconstruction to Magnetic Resonance Imaging of Canine Stifle Joint in Healthy Beagles: Achieving Enhanced Image Quality With Reduced Slice Thickness.Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association · 2026
    Article
  4. Review
  5. Article
  6. Deep learning in fetal, infant, and toddler neuroimaging research.Developmental cognitive neuroscience · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Utility of Thin-slice Single-shot T2-weighted MR Imaging with Deep Learning Reconstruction as a Protocol for Evaluating Pancreatic Cystic Lesions.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025
    Article
  12. Article
  13. Deep Learning-Based Image Reconstruction in Musculoskeletal MRI.Journal of the Korean Society of Radiology · 2025
    Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

83 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Akshay S ChaudhariDepartment of Radiology, Stanford University, Stanford, California.ORCID 0000-0002-3667-6796
Zhongnan FangLVIS Corporation, Palo Alto, California.
Feliks KoganDepartment of Radiology, Stanford University, Stanford, California.
Jeff WoodDepartment of Radiology, Stanford University, Stanford, California.
Kathryn J StevensDepartment of Radiology, Stanford University, Stanford, California.
Eric K GibbonsDepartment of Radiology and Imaging Sciences, University of Utah, Salt Lake City, Utah.
Jin Hyung LeeDepartment of Bioengineering, Stanford University, Stanford, California.
Garry E GoldDepartment of Radiology, Stanford University, Stanford, California.
Brian A HargreavesDepartment of Radiology, Stanford University, Stanford, California.

Funding

Training and DisseminationP41EB015891 · NIBIB · STANFORD UNIVERSITY · PI GLOVER, GARY H · 2012 to 2019
$10.7M
TRAINING IN CARDIOVASCULAR RESEARCHT32HL007576 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Stavros George Drakos, Robin M Shaw · 1985 to 2026
$10.6M
Rapid MRI for Evaluation of OsteoarthritisR01EB002524 · NIBIB · STANFORD UNIVERSITY · PI Akshay Chaudhari, Garry E Gold · 2003 to 2026
$10.1M
Quantitative 3D Diffusion and Relaxometry MRI of the KneeR01AR063643 · NIAMS · STANFORD UNIVERSITY · PI HARGREAVES, BRIAN ANDREW · 2013 to 2017
$2.5M
Advanced MR Imaging of Early OsteoarthritisK24AR062068 · NIAMS · STANFORD UNIVERSITY · PI GOLD, GARRY E · 2012 to 2022
$1.7M
CLINICAL CENTER FOR THE OSTEOARTHRITIS-264022262-264022262N01AR022262 · NIAMS · THE MEMORIAL HOSPITAL · PI ASSAF, ANNLOUISE R. · 2002 to 2006
–
CLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVE-N01AR22261N01AR022261 · NIAMS · OHIO STATE UNIVERSITY RESEARCH · PI JACKSON, REBECCA · 2002 to 2006
–
CLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVE-N01AR22260N01AR022260 · NIAMS · UNIVERSITY OF PITTSBURGH · PI KWOH, KENT · 2002 to 2006
–
CLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVE-264022259-264022259N01AR022259 · NIAMS · UNIVERSITY OF MARYLAND AT BALT · PI HOCHBERG, MARC C. · 2002 to 2006
–
DATA COORDINATING CENTER FOR THE OSTEOARTHRITIS INITIATIVE-264022258N01AR022258 · NIAMS · UNIVERSITY OF CALIFORNIA SYS OFFICE/PRES · 2003 to 2003
–
NHLBI NIH HHS T32 HL007576NIAMS NIH HHS K24 AR062068NIAMS NIH HHS N01 AR022258NIAMS NIH HHS N01 AR022259NIAMS NIH HHS N01 AR022260NIAMS NIH HHS N01 AR022261NIAMS NIH HHS N01 AR022262NIAMS NIH HHS R01 AR063643NIBIB NIH HHS P41 EB015891NIBIB NIH HHS R01 EB002524
6 · The paper itself

Abstract

purposeTo develop a super-resolution technique using convolutional neural networks for generating thin-slice knee MR images from thicker input slices, and compare this method with alternative through-plane interpolation methods.

methodsWe implemented a 3D convolutional neural network entitled DeepResolve to learn residual-based transformations between high-resolution thin-slice images and lower-resolution thick-slice images at the same center locations. DeepResolve was trained using 124 double echo in steady-state (DESS) data sets with 0.7-mm slice thickness and tested on 17 patients. Ground-truth images were compared with DeepResolve, clinically used tricubic interpolation, and Fourier interpolation methods, along with state-of-the-art single-image sparse-coding super-resolution. Comparisons were performed using structural similarity, peak SNR, and RMS error image quality metrics for a multitude of thin-slice downsampling factors. Two musculoskeletal radiologists ranked the 3 data sets and reviewed the diagnostic quality of the DeepResolve, tricubic interpolation, and ground-truth images for sharpness, contrast, artifacts, SNR, and overall diagnostic quality. Mann-Whitney U tests evaluated differences among the quantitative image metrics, reader scores, and rankings. Cohen's Kappa (κ) evaluated interreader reliability.

resultsDeepResolve had significantly better structural similarity, peak SNR, and RMS error than tricubic interpolation, Fourier interpolation, and sparse-coding super-resolution for all downsampling factors (p < .05, except 4 × and 8 × sparse-coding super-resolution downsampling factors). In the reader study, DeepResolve significantly outperformed (p < .01) tricubic interpolation in all image quality categories and overall image ranking. Both readers had substantial scoring agreement (κ = 0.73).

conclusionDeepResolve was capable of resolving high-resolution thin-slice knee MRI from lower-resolution thicker slices, achieving superior quantitative and qualitative diagnostic performance to both conventionally used and state-of-the-art methods.

Indexed as

Deep LearningAlgorithmsCartilage DiseasesHumansImaging, Three-DimensionalKneeMagnetic Resonance ImagingOsteoarthritis, KneePhantoms, ImagingPilot ProjectsSignal-To-Noise Ratiodeep learninginterpolationisotropic MRImusculoskeletal MRIsuper-resolutionunsupervised sparsity learning

Identifiers

PMID29582464
PMCPMC6107420

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.