ArticleJournal of the American Geriatrics Society2018
National Prescribing Trends for High-Risk Anticholinergic Medications in Older Adults.
Article in Journal of the American Geriatrics Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prevalence and factors associated with anticholinergic medication use in community-dwelling older adults: a systematic review.International journal of clinical pharmacy · 2025Pooled it
- The effects of anticholinergic medications on cognition in children: a systematic review and meta-analysis.Scientific reports · 2021Pooled it
- Impact of TCAs and Gabapentin on Saliva and BMI in Adults With Xerostomia.Journal of oral rehabilitation · 2026Article
- Temporal Trends of Anticholinergic Drug Exposure Among Older Adults: A 25-Year Population-Based Study.Drug safety · 2025Article
- Pharmacogenetic associations ofFrontiers in pharmacology · 2025Article
- Disentangling drug contributions: anticholinergic burden in older adults linked to individual medications: a cross-sectional population-based study.BMC geriatrics · 2024Article
- Psychotropic medication use and future unexplained and injurious falls and fracture amongst community-dwelling older people: data from TILDA.European geriatric medicine · 2023Article
- Potentially Inappropriate Medication Use in Older Adults with Alzheimer's Disease and Related Dementias Living in the Community: A Cross-Sectional Analysis.Drugs - real world outcomes · 2021Article
- Polypharmacy among older adults with dementia compared with those without dementia in the United States.Journal of the American Geriatrics Society · 2021Article
- A Critical Review of the Study of Neuroprotective Diets to Reduce Cognitive Decline.Nutrients · 2021Review
- Quantifying cumulative anticholinergic and sedative drug load among US Medicare Beneficiaries.Pharmacoepidemiology and drug safety · 2021Article
- Rationale and design of the Novel Uses of adaptive Designs to Guide provider Engagement in Electronic Health Records (NUDGE-EHR) pragmatic adaptive randomized trial: a trial protocol.Implementation science : IS · 2021Article
- Decrease of Anticholinergic Drug Use in Nursing Home Residents in the United States, 2009 to 2017.Journal of the American Geriatrics Society · 2020Article
- Increasing prevalence of anticholinergic medication use in older people in England over 20 years: cognitive function and ageing study I and II.BMC geriatrics · 2020Article
- A multiyear cross-sectional study of U.S. national prescribing patterns of first-generation sedating antihistamines in older adults with skin disease.The British journal of dermatology · 2020Observational
- Temporal Trends in the Use of Anticholinergic Drugs Among Older People Living in Long-Term Care Facilities in Helsinki.Drugs & aging · 2020Article
- Coprescribing of Benzodiazepines and Opioids in Older Adults: Rates, Correlates, and National Trends.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- Buprenorphine prescribing for opioid use disorder in medical practices: can office-based out-patient care address the opiate crisis in the United States?Addiction (Abingdon, England) · 2019Article
- Anticholinergic and benzodiazepine medication use and risk of incident dementia: a UK cohort study.BMC geriatrics · 2019Article
- Extent and Predictors of Potentially Inappropriate Antidepressant Use Among Older Adults With Dementia and Major Depressive Disorder.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectivesTo estimate prescribing tends of and correlates independently associated with high-risk anticholinergic prescriptions in adults aged 65 and older in office-based outpatient visits.
designRepeated cross-sectional analysis.
settingNational Ambulatory Medical Care Survey (NAMCS).
participantsA national sample of office-based physician visits by adults aged 65 and older from 2006 to 2015 (n=96,996 unweighted). MEASUREMENTS: Prescriptions of high-risk anticholinergics, regardless of indication, were identified, and overall prescribing trends were estimated from 2006 to 2015. Stratified analyses of prescribing trends according to physician specialty and anticholinergic drug class were also performed. We used a multivariable logistic regression analysis to estimate the odds of high-risk anticholinergic prescription.
resultsBetween 2006 and 2015, a high-risk anticholinergic prescription was listed for 5,876 (6.2%) 96,996 visits of older adults, representative of 14.6 million total visits nationally. The most common drug classes were antidepressants, antimuscarinics, and antihistamines, which accounted for more than 70% of prescribed anticholinergics. Correlates independently associated with greater odds of receiving a high-risk anticholinergic prescription were female sex, the Southern geographic region, specific physician specialties (e.g., psychiatry, urology), receipt of 6 or more concomitantly prescribed medications, and related clinical diagnoses (e.g., urinary continence) (p<.01 for all).
conclusionThe prevalence of high-risk anticholinergic prescriptions was stable over time but varied according to physician specialty and drug class. Quality prescribing should be promoted because safer alternatives are available.
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