ArticleInternational ophthalmology2019
Corneal densitometry after accelerated corneal collagen cross-linking in progressive keratoconus.
Article in International ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Pulsed corneal crosslinking in the treatment of Keratoconus: a systematic review and meta-analysis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Pooled it
- Changes in Corneal Densitometry and Relationship to Corneal Topographical Parameters in Accelerated Corneal Crosslinking for the Treatment of Keratoconus.Journal of clinical medicine · 2026Article
- Comparative Analysis of Corneal Densitometry Changes Following Standard Versus Accelerated Corneal Cross-Linking Protocol.Medicina (Kaunas, Lithuania) · 2025Article
- Influencing Factors in Corneal Densitometry Recovery After Accelerated Cross-Linking for Keratoconus.Journal of ophthalmology · 2025Article
- Could Automated Objective Measurements Acquired at the Preoperative Stage Estimate the Corrected Distance Visual Acuity after Corneal Cross-Linking in Keratoconus?Ophthalmology and therapy · 2024Article
- The Impact of Standard Cross-Linking on the Corneal Optical Density-Age Relationship in Keratoconus After Mechanical Stripping of the Epithelium.Journal of ophthalmology · 2024Article
- Distribution of 50-layer corneal densitometry values and related factors.International ophthalmology · 2023Article
- One-year non-comparative observational study to evaluate corneal tomographic, densitometric, and aberrometric features following accelerated corneal cross-linking in progressive keratoconus.International ophthalmology · 2023Observational
- Corneal densitometry in bilateral keratoconus patients with unilateral corneal Vogt's striae: a contralateral eye study.International ophthalmology · 2023Article
- Corneal optical density: Structural basis, measurements, influencing factors, and roles in refractive surgery.Frontiers in bioengineering and biotechnology · 2023Review
- [Histological changes in keratoconus and wound healing after corneal cross-linking].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2022Review
- Factors influencing haze formation and corneal flattening, and the impact of haze on visual acuity after conventional collagen cross-linking: a 12-month retrospective study.BMC ophthalmology · 2021Article
- Intrastromal implantation of chicken corneal grafts into the cornea of rabbits for corneal thickening: an experimental study.International ophthalmology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo analyze changes in corneal densitometry 3 months after accelerated corneal collagen cross-linking (CXL) measured with Scheimpflug tomography.
methodsIn this study we reviewed charts and anterior segment data of patients who had undergone accelerated pulsed epithelium-off CXL (30 mW/cm
resultsThe study investigated 12 eyes of 12 patients. The anterior (120 μm) stromal layer within the 0.0 to 2.0 mm and 2.0 to 6.0 mm concentric zones showed a significant elevation of mean densitometry 3 months post-surgery (P = 0.045; P = 0.015) compared to baseline. A mean stromal demarcation line was apparent at a depth of 203.00 μm ± 13.53 (SD). After accelerated CXL, no change in mean corrected distance visual acuity (LogMAR) was observed but a thinning of the cornea measured by a significant reduction in central pachymetry (μm).
conclusionAccelerated CXL results in an increase in corneal densitometry, particularly in the anterior stromal layer within the two central concentric zones (0.0 to 2.0 mm and 2.0 to 6.0 mm) of the cornea at 3 months postoperatively. The changes in corneal densitometry of the anterior stromal layer did not correlate with postoperative visual acuity or central pachymetry.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.