Evidence map›Paper›PMID 29582201›Full record

ArticleCytotechnology2018

Friedelane, isolated from Pouzolzia indica Gaud. exhibits toxic effect against melanoma.

Debasish Maiti, Ashish Kumar Singha, Chaitali Sarkar, Soham Sarkar, Indrajit Sil Sarma, Kuntal Manna, Biswanath Dinda

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cytotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Debasish MaitiImmunology Microbiology Lab, Department of Human Physiology, Tripura University, Suryamaninagar, Agartala, 799 022, India. debasish.maiti@tripurauniv.in.
Ashish Kumar SinghaImmunology Microbiology Lab, Department of Human Physiology, Tripura University, Suryamaninagar, Agartala, 799 022, India.
Chaitali SarkarImmunology Microbiology Lab, Department of Human Physiology, Tripura University, Suryamaninagar, Agartala, 799 022, India.
Soham SarkarWilson's School, Mollison Drive, Wallington, SM6 9JW, UK.
Indrajit Sil SarmaTripura State Forensic Science Laboratory, Narasingarh, Agartala, 799 015, India.
Kuntal MannaDepartment of Pharmacy, Tripura University, Suryamaninagar, Agartala, 799022, India.
Biswanath DindaDepartment of Chemistry, Tripura University, Suryamaninagar, Agartala, 799 022, India.
Tripura University · IN

Funding

DBT, Govt of India BT/04/NE/2009 Dated 22/12/2010
6 · The paper itself

Abstract

Melanoma is a predominant cause of skin cancer-related deaths. It was reported that, the methanolic extract of Pouzolzia Indica (P. indica) on chromatography gave five compounds (1-hentriacontanyl palmitate, myricyl alcohol, 6,7-dimethoxycoumarin, trichadonic acid and friedelane), which inhibited the acute promyelocytic leukemia cell lines, NB4, and HT93A. Friedelane was extracted as active compound from methanolic extract of P. indica. In this study, friedelane was tested on murine metastatic B16F10 and B16BL6 melanoma cell lines. To achieve the target, the cell viability using trypan blue exclusion, acridine orange/EtBr staining and cell cytotoxicity were tested using MTT assay. Caspase-3, caspase-9, Cyt-c, BAD and Bax protein were assayed to evidence the apoptosis induction. The compound friedelane shows potent cytotoxic effect against metastatic melanoma mouse cell lines in 10 µg/ml concentration.

Indexed as

ApoptosisCell viabilityCytotoxicityFriedelane (Fr)MelanomaPauzolzia indica Gaud.

Identifiers

PMID29582201
PMCPMC6081928
OpenAlexW2795880941

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.