Evidence map›Paper›PMID 29582172›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2018

Gender differences in the presentation of dysphonia related to laryngopharyngeal reflux disease: a case-control study.

Jérôme R Lechien, Kathy Huet, Mohamad Khalife, Anne-Françoise Fourneau, Camille Finck, Véronique Delvaux, Myriam Piccaluga, Bernard Harmegnies, Sven Saussez

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In one paragraph

Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 26 citations in OpenAlex.

  1. Lansoprazole for persistent throat symptoms in secondary care: the TOPPITS RCT.Health technology assessment (Winchester, England) · 2021
    Trial
  2. Article
  3. Review
  4. [The application progress on diagnostic scales of laryngopharyngeal reflux disease].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2023
    Review
  5. Post-COVID-19 Dysphonia may have Several Origins.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022
    Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Jérôme R LechienLaboratory of Anatomy and Cell Biology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Avenue du Champ de mars, 6, 7000, Mons, Belgium. jerome.lechien@umons.ac.be.ORCID http://orcid.org/0000-0002-0845-0845
Kathy HuetLaboratory of Phonetics, Faculty of Psychology, Research Institute for Language sciences and Technology, University of Mons (UMons), Mons, Belgium.
Mohamad KhalifeDepartment of Otorhinolaryngology and Head and Neck Surgery, EpiCURA Hospital, UMONS-EpiCURA Research plateform, Baudour, Belgium.
Anne-Françoise FourneauDepartment of Otorhinolaryngology and Head and Neck Surgery, EpiCURA Hospital, UMONS-EpiCURA Research plateform, Baudour, Belgium.
Camille FinckDepartment of Otorhinolaryngology and Head and Neck Surgery, CHU de Liège, Liege, Belgium.
Véronique DelvauxLaboratory of Phonetics, Faculty of Psychology, Research Institute for Language sciences and Technology, University of Mons (UMons), Mons, Belgium.
Myriam PiccalugaLaboratory of Phonetics, Faculty of Psychology, Research Institute for Language sciences and Technology, University of Mons (UMons), Mons, Belgium.
Bernard HarmegniesLaboratory of Phonetics, Faculty of Psychology, Research Institute for Language sciences and Technology, University of Mons (UMons), Mons, Belgium.
Sven SaussezLaboratory of Anatomy and Cell Biology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Avenue du Champ de mars, 6, 7000, Mons, Belgium.
University of Mons · BEEpicura · BECentre Hospitalier Universitaire de Liège · BE

Funding

ARC Communauté Francaise N°AUWB-2012-12/17-UMONS
6 · The paper itself

Abstract

objectiveTo investigate the voice quality impairments in patients with laryngopharyngeal reflux (LPR) according to the gender.

designControlled multi-center study. MATERIALS AND

methods80 LPR patients (40 males and 40 females) with reflux finding score (RFS) > 7 and reflux symptom index (RSI) > 13 were included and clinically compared according to gender. To be considered as LPR patients, subjects responded to an empiric therapeutic trial based on pantoprazole intake and diet recommendations for 3 months or had positive pH/Impedance metry. Voice Handicap Index (VHI); Short Form Healthy Survey 36 (SF36), blinded Grade, Roughness, Breathiness, Asthenia, Strain and Instability (GRBASI); aerodynamic and acoustic measurements were assessed in all patients and compared with 80 healthy controls (40 males and 40 females) according to gender.

resultsThe most common reasons for the consultation were, respectively, globus sensation in males (22.5%) and dysphonia (27.5%) in female who complained more of breathing difficulties and choking episodes related to LPR than males (p = 0.024). From a quality of life standpoint, female had increased significant impact of LPR disease on vitality and mental health than male. Compared to healthy subjects, both LPR male and female patients had stronger values of G, R, B, S, I, VHI, percent jitter, percent shimmer, and soft palate index than controls. In addition, LPR female had stronger values of lowest fundamental frequency and all aerodynamic measurements than controls.

conclusionAs showed in many other laryngeal conditions, voice quality of female could be more impaired by LPR than male. Some anatomical, histological and functional factors can be suspected and need additional future researches.

Indexed as

Quality of LifeVoice Quality2-PyridinylmethylsulfinylbenzimidazolesAdultCase-Control StudiesDysphoniaFemaleHoarsenessHumansLaryngopharyngeal RefluxMaleMiddle AgedPantoprazoleSex Factors2-PyridinylmethylsulfinylbenzimidazolesPantoprazoleLaryngitisLaryngopharyngealRefluxVoice

Identifiers

PMID29582172
OpenAlexW2789637297

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.