Evidence map›Paper›PMID 29582143›Full record

ReviewJournal of neurology2018

Genetic contribution to vestibular diseases.

Alvaro Gallego-Martinez, Juan Manuel Espinosa-Sanchez, Jose Antonio Lopez-Escamez

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  15. European Position Statement on Diagnosis, and Treatment of Meniere's Disease.The journal of international advanced otology · 2018
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Alvaro Gallego-MartinezOtology and Neurotology Group CTS495, Department of Genomic Medicine, Centre for Genomics and Oncological Research-Pfizer/University of Granada/Andalusian Regional Government (GENYO), Avda de la Ilustración, 114, 18016, Granada, Spain.
Juan Manuel Espinosa-SanchezOtology and Neurotology Group CTS495, Department of Genomic Medicine, Centre for Genomics and Oncological Research-Pfizer/University of Granada/Andalusian Regional Government (GENYO), Avda de la Ilustración, 114, 18016, Granada, Spain.
Jose Antonio Lopez-EscamezOtology and Neurotology Group CTS495, Department of Genomic Medicine, Centre for Genomics and Oncological Research-Pfizer/University of Granada/Andalusian Regional Government (GENYO), Avda de la Ilustración, 114, 18016, Granada, Spain. antonio.lopezescamez@genyo.es.ORCID http://orcid.org/0000-0002-8583-1430

Funding

Fonds National de la Recherche Luxembourg INTER/Mobility/17/11772209H2020 Marie Skłodowska-Curie Actions ITN-2016-722046ISCIII PI17/01644Meniere Society, UK MS-2016-17 Grant
6 · The paper itself

Abstract

Growing evidence supports the contribution of allelic variation to vestibular disorders. Heritability attributed to rare allelic variants is found in familial vestibular syndromes such as enlarged vestibular aqueduct syndrome or familial Meniere disease. However, the involvement of common allelic variants as key regulators of physiological processes in common and rare vestibular diseases is starting to be deciphered, including motion sickness or sporadic Meniere disease. The genetic contribution to most of the vestibular disorders is still largely unknown. This review will outline the role of common and rare variants in human genome to episodic vestibular syndromes, progressive vestibular syndrome, and hereditary sensorineural hearing loss associated with vestibular phenotype. Future genomic studies and network analyses of omic data will clarify the pathway towards a personalized stratification of treatments.

Indexed as

HumansVestibular DiseasesDizzinessGeneticsMeniere diseaseVestibular disordersVestibular migraine

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.