Evidence map›Paper›PMID 29582111›Full record

ArticleClinical neuroradiology2019

Clinical Utility of Diffusion-Weighted Imaging in Spinal Infections.

Rebecca A Dumont, Nayela N Keen, Courtnay W Bloomer, Brian S Schwartz, Jason Talbott, Aaron J Clark, David M Wilson, Cynthia T Chin

Open access · greenAbstract read
In one paragraph

Article in Clinical neuroradiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Diagnostic imaging confusion in infectious spondylitis.Journal of orthopaedic surgery and research · 2025
    Review
  5. Article
  6. Imaging assessment of spine infection.Skeletal radiology · 2024
    Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Chemoenzymatic Syntheses of Fluorine-18-Labeled Disaccharides from [Journal of the American Chemical Society · 2023
    Article
  13. Review
  14. Article
  15. Magnetic Resonance Imaging for Spine Emergencies.Magnetic resonance imaging clinics of North America · 2022
    Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Rebecca A DumontDepartment of Radiology and Biomedical Imaging, University of California San Francisco, 505 Parnassus Avenue, Rm. L-358, 94143-0628, San Francisco, CA, USA.
Nayela N KeenDepartment of Radiology and Biomedical Imaging, University of California San Francisco, 505 Parnassus Avenue, Rm. L-358, 94143-0628, San Francisco, CA, USA.
Courtnay W BloomerDepartment of Radiology and Biomedical Imaging, University of California San Francisco, 505 Parnassus Avenue, Rm. L-358, 94143-0628, San Francisco, CA, USA.
Brian S SchwartzDepartment of Medicine, University of California San Francisco, San Francisco, USA.
Jason TalbottDepartment of Radiology and Biomedical Imaging, University of California San Francisco, 505 Parnassus Avenue, Rm. L-358, 94143-0628, San Francisco, CA, USA.
Aaron J ClarkDepartment of Neurosurgery, University of California San Francisco, San Francisco, USA.
David M WilsonDepartment of Radiology and Biomedical Imaging, University of California San Francisco, 505 Parnassus Avenue, Rm. L-358, 94143-0628, San Francisco, CA, USA. David.M.Wilson@ucsf.edu.
Cynthia T ChinDepartment of Radiology and Biomedical Imaging, University of California San Francisco, 505 Parnassus Avenue, Rm. L-358, 94143-0628, San Francisco, CA, USA. Cynthia.T.Chin@ucsf.edu.
University of California, San Francisco · US

Funding

Development of 11C-PABA as a bacteria-specific imaging agent for spinal infectionsR01EB025985 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JAIN, SANJAY, WILSON, DAVID M · 2018 to 2021
$2.7M
Clinical translation of D-amino acid derived PET tracers for imaging spinalinfectionR01EB024014 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI OHLIGER, MICHAEL, WILSON, DAVID M · 2017 to 2020
$2.2M
NIBIB NIH HHS R01 EB024014NIBIB NIH HHS R01 EB025985NIBIB NIH HHS RO1 EB024014RSNA Research and Education Foundation RF1622
6 · The paper itself

Abstract

purposeBoth laboratory markers and radiographic findings in the setting of spinal infections can be nonspecific in determining the presence or absence of active infection, and can lag behind both clinical symptoms and antibiotic response. Magnetic resonance imaging (MRI) with diffusion-weighted imaging (DWI) has been shown to be helpful in evaluating brain abscesses but has not been commonly used in evaluating spinal infections. We aimed to correlate findings on DWI of the spine to results of microbiological sampling in patients with suspected spinal infections.

methodsPatients who underwent MRI with DWI for suspicion of spinal infections and microbiological sampling from 2002 to 2010 were identified and reviewed retrospectively in this institutional review board approved study. In addition to DWI, scans included sagittal and axial T1, fast-spin echo (FSE) T2, and post-gadolinium T1 with fat saturation. Regions of interest were drawn on apparent diffusion coefficient (ADC) maps in the area of suspected infections, and ADC values were correlated with microbiological sampling.

resultsOf 38 patients with suspected spinal infections, 29 (76%) had positive microbiological sampling, and 9 (24%) had negative results. The median ADC value was 740 × 10

conclusionIn patients with suspected spine infection, ADC values on DWI are significantly reduced in those patients with positive microbiological sampling compared to patients with negative microbiological sampling. The DWI of the spine correlates well with the presence or absence of spinal infection and may complement conventional magnetic resonance imaging (MRI).

Indexed as

AdultAgedAged, 80 and overCentral Nervous System Bacterial InfectionsCross-Sectional StudiesDiffusion Magnetic Resonance ImagingDiscitisFemaleHumansImmunocompromised HostMaleMiddle AgedOsteomyelitisRetrospective StudiesRisk FactorsSpinal DiseasesBacterial infectionDiffusion weighted imagingMRIRadiology-pathology correlationVertebral Discitis-Osteomyelitis

Identifiers

PMID29582111
PMCPMC6158113
OpenAlexW2792545550

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.