ArticleScience advances2018
Oriented chiral water wires in artificial transmembrane channels.
Article in Science advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 103 citations in OpenAlex.
- Selective Nitrate Transmembrane Transport Through Adaptive Weak C─H Bonding Cyanostilbene Water Channels.Angewandte Chemie (International ed. in English) · 2026Article
- Stepwise Hydration Reveals Conformational Switching in Chiral Prolinol.Journal of the American Chemical Society · 2025Article
- Interfacial Self-Assembly of Sugars at Nanoscale Membranes Leads to Micron-Scale, Spectroscopically Ice-Like Chiral Suprastructures of Water.Journal of the American Chemical Society · 2025Article
- Coupling between electrons' spin and proton transfer in chiral biological crystals.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Water-Mediated Chiral Resolution of Ag-NHC(Nucleobase) Complexes.Inorganic chemistry · 2025Article
- Rubbery organic frameworks (ROFs) toward ultrapermeable COScience advances · 2024Article
- Proton Conduction in Chiral Molecular Assemblies of Azolium-Camphorsulfonate Salts.Journal of the American Chemical Society · 2024Article
- Probing the structure of water in individual living cells.Nature communications · 2024Article
- Selective and rapid water transportation across a self-assembled peptide-diol channelChemical science · 2022Article
- Article
- Controlling Water Flow through a Synthetic Nanopore with Permeable Cations.ACS central science · 2021Article
- Simulation of the Chiral Sum Frequency Generation Response of Supramolecular Structures Requires Vibrational Couplings.The journal of physical chemistry. B · 2021Article
- Tunable membranes incorporating artificial water channels for high-performance brackish/low-salinity water reverse osmosis desalination.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Biomimetic artificial water channel membranes for enhanced desalination.Nature nanotechnology · 2021Article
- Handy water: Chiral superstructures around peptide β-sheets.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Water in Nanopores and Biological Channels: A Molecular Simulation Perspective.Chemical reviews · 2020Review
- Functional stability of water wire-carbonyl interactions in an ion channel.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Polarimetric Measurements of Surface Chirality Based on Linear and Nonlinear Light Scattering.Frontiers in chemistry · 2020Review
- Chiral Water Superstructures around Antiparallel β-Sheets Observed by Chiral Vibrational Sum Frequency Generation Spectroscopy.The journal of physical chemistry letters · 2019Article
- Artificial Gramicidins.Frontiers in chemistry · 2019Review
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aquaporins (AQPs) feature highly selective water transport through cell membranes, where the dipolar orientation of structured water wires spanning the AQP pore is of considerable importance for the selective translocation of water over ions. We recently discovered that water permeability through artificial water channels formed by stacked imidazole I-quartet superstructures increases when the channel water molecules are highly organized. Correlating water structure with molecular transport is essential for understanding the underlying mechanisms of (fast) water translocation and channel selectivity. Chirality adds another factor enabling unique dipolar oriented water structures. We show that water molecules exhibit a dipolar oriented wire structure within chiral I-quartet water channels both in the solid state and embedded in supported lipid bilayer membranes (SLBs). X-ray single-crystal structures show that crystallographic water wires exhibit dipolar orientation, which is unique for chiral I-quartets. The integration of I-quartets into SLBs was monitored with a quartz crystal microbalance with dissipation, quantizing the amount of channel water molecules. Nonlinear sum-frequency generation vibrational spectroscopy demonstrates the first experimental observation of dipolar oriented water structures within artificial water channels inserted in bilayer membranes. Confirmation of the ordered confined water is obtained via molecular simulations, which provide quantitative measures of hydrogen bond strength, connectivity, and the stability of their dipolar alignment in a membrane environment. Together, uncovering the interplay between the dipolar aligned water structure and water transport through the self-assembled I-quartets is critical to understanding the behavior of natural membrane channels and will accelerate the systematic discovery for developing artificial water channels for water desalting.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.