Evidence map›Paper›PMID 29581800›Full record

ArticleJournal of clinical medicine research2018

Impact of Drug Induced Long QT Syndrome: A Systematic Review.

Karuppiah Arunachalam, Seetha Lakshmanan, Abhishek Maan, Narendra Kumar, Paari Dominic

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 51 citations in OpenAlex.

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  12. Oxytocin exerts harmful cardiac repolarization prolonging effects in drug-induced LQTS.International journal of cardiology. Heart & vasculature · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

Karuppiah ArunachalamWarren Alpert Medical School of Brown University, Providence, RI, USA.
Seetha LakshmananAsian Institute of Medicine, Science and Technology, Sungai Petani, Malaysia, Malaysia.
Abhishek MaanWarren Alpert Medical School of Brown University, Providence, RI, USA.
Narendra KumarParas HMRI Hospital, Patna, India.
Paari DominicCenter for Cardiovascular Diseases and Sciences, LSU Health Sciences Center, Shreveport, Louisiana, LA, USA.
Brown University · USAIMST University · MYLouisiana State University Health Sciences Center Shreveport · USParas Hospitals · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDrug induced long QT syndrome is quite common in daily clinical practice but its impact is unknown.

methodsPubMed and EMBASE databases (until May 2, 2017) were searched to identify studies reporting drug induced long QT syndrome and followed the PRISMA guidelines. The main outcomes measured in these studies were QTc prolongation, ventricular arrhythmias, torsade de pointes (TdP) and death.

resultsOut of 176 non-duplicate reports, 36 studies satisfied inclusion criteria and provided data on patients exposed to drugs that can potentially cause long QT. Totally, 14,756 patients were exposed and 930 patients (6.3%) were found to have QTc prolongation. The number of males was 6,400 and females were 5,723 patients. The mean age of the patients was 43.8 ± 9.36 years. Ventricular arrhythmias were found in 379 patients (2.6%), 26 patients were found to have premature atrial contractions (PACs) and premature ventricular contractions (PVCs). TdP was found in 49 patients (0.33 %), sudden cardiac death (SCD) was found in five patients and 586 patients were found to have all-cause mortality.

conclusionsAround 6% of patients have risk of QT prolongation when exposed but only 0.3% developed TdP and 2.6% developed ventricular arrhythmias. Risk of developing arrhythmias is higher with concomitant use of multiple QT prolonging drugs.

Indexed as

QTc prolongationSudden cardiac deathTorsades de pointes

Identifiers

PMID29581800
PMCPMC5862085
OpenAlexW2789597832

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.