ArticleJournal of geriatric cardiology : JGC2017
Effect of advanced age on plasma homocysteine levels and its association with ischemic stroke in non-valvular atrial fibrillation.
Article in Journal of geriatric cardiology : JGC, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Efficacy and safety of folic acid on homocysteine and cardiovascular surrogate biomarkers in hyperhomocysteinemia: a systematic review and meta-analysis of RCTs.BMC nutrition · 2026Pooled it
- The relationship between thyroid hormones sensitivity and hyperhomocysteinemia: a cross-sectional study based on Chinese health check-up population.Frontiers in endocrinology · 2025Article
- Comparison of the Metabolomics of DifferentInternational journal of molecular sciences · 2023Article
- Modulation of DNA methylation by one-carbon metabolism: a milestone for healthy aging.Nutrition research and practice · 2023Review
- Plasma Total Homocysteine Level Is Related to Unfavorable Outcomes in Ischemic Stroke With Atrial Fibrillation.Journal of the American Heart Association · 2022Article
- Combined Effect of Homocysteine and Uric Acid to Identify Patients With High Risk for Subclinical Atrial Fibrillation.Journal of the American Heart Association · 2022Article
- Homocysteine metabolism as the target for predictive medical approach, disease prevention, prognosis, and treatments tailored to the person.The EPMA journal · 2021Review
- Hyperhomocysteinemia and Ischemic Stroke: A Potential Dose-Response Association-A Systematic Review and Meta-analysis.TH open : companion journal to thrombosis and haemostasis · 2021Review
- Gender differences in risk factors for high plasma homocysteine levels based on a retrospective checkup cohort using a generalized estimating equation analysis.Lipids in health and disease · 2021Article
- Factors associated with hyperhomocysteinemia in relatively healthy Taiwanese adults: A retrospective medical record study.Medicine · 2021Article
- A Review of Biomarkers for Ischemic Stroke Evaluation in Patients With Non-valvular Atrial Fibrillation.Frontiers in cardiovascular medicine · 2021Review
- Association between gene promoter methylation of the one-carbon metabolism pathway and serum folate among patients with hyperhomocysteinemia.European journal of clinical nutrition · 2020Article
- Plasma Homocysteine Concentration is Associated with the Expression Level of Folate Receptor 3.Scientific reports · 2020Observational
- Cys34 Adductomics Links Colorectal Cancer with the Gut Microbiota and Redox Biology.Cancer research · 2019Article
- Case series of retinal vein occlusions showing early recovery using oral l-methylfolate.Therapeutic advances in ophthalmologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundElevated homocysteine (Hcy) has been reported to be associated with cardiovascular events in atrial fibrillation (AF) patients, while the age-related expression pattern of plasma Hcy in AF remains unknown. The study was aimed to investigate the effect of advanced age on plasma Hcy levels and its association with ischemic stroke in non-valvular AF patients.
methodsA total of 2562 consecutive patients with non-valvular AF and 535 controls were enrolled and divided into six age groups. Plasma Hcy levels were analyzed among different age groups, and the effect of advanced age on Hcy was investigated.
resultsPlasma Hcy levels did not show any difference among groups aged below 65 years, while it increased sharply in patients aged 65-74 years and aged over 75 years (15.7 ± 4.6 µmol/L, 17.1 ± 4.9 µmol/L, both
conclusionsAdvanced age was significantly associated with elevated Hcy levels, which may provide a possible explanation for the progressive increase in ischemic stroke especially in elderly AF patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.