ArticleJournal of geriatric cardiology : JGC2017
Predictors of super-response to cardiac resynchronization therapy: the significance of heart failure medication, pre-implant left ventricular geometry and high percentage of biventricular pacing.
Article in Journal of geriatric cardiology : JGC, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- QRS Index as a Predictor of Response to Cardiac Resynchronization Therapy: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Visceral Adipose Tissue Cut Points for Increased Metabolic Risk in Chinese Adults Using Low-Dose Computed Tomography: A Nationwide Multicenter Study.Obesity facts · 2026Article
- Analyzing Insights of Super-Response in Cardiac Resynchronization Therapy with Fusion Pacing.Diagnostics (Basel, Switzerland) · 2025Article
- Investigating the clinical utility of global and regional myocardial work parameters in predicting response to cardiac resynchronization therapy in patients with heart failure and reduced ejection fraction.Quantitative imaging in medicine and surgery · 2024Article
- Response predictors to cardiac resynchronization therapy in chronic heart failure: a 10-year-cardiovascular center experience.Archivos de cardiologia de Mexico · 2024Article
- Clinical and gated SPECT MPI parameters associated with super-response to cardiac resynchronization therapy.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Atrial fibrillation associated with heart failure treated by a 2-lead CRT-DX system (BIO-AffectDX): Study design and clinical protocol.Heart rhythm O2 · 2021Article
- Heart failure treatment in patients with cardiac implantable electronic devices: Opportunity for improvement.Heart rhythm O2 · 2021Article
- Feasibility and First Results of Heart Failure Monitoring Using the Wearable Cardioverter-Defibrillator in Newly Diagnosed Heart Failure with Reduced Ejection Fraction.Sensors (Basel, Switzerland) · 2021Article
- Delayed spontaneous reversibility of left bundle branch block in non-ischemic cardiomyopathy: a case report.Journal of geriatric cardiology : JGC · 2020Article
- Echocardiographic markers of dyssynchrony as predictors of super-response to cardiac resynchronisation therapy - a pilot study.Cardiovascular ultrasound · 2018Article
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Authors and funding
9 authors.
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Abstract
backgroundSuper-responders (SRs) are defined as patients who show crucial cardiac function improvement after cardiac resynchronization therapy (CRT). The purpose of this study is to identify and validate predictors of SRs after CRT.
methodsThis study enrolled 201 patients who underwent CRT during the period from 2010 to 2014. Clinical and echocardiographic evaluations were conducted before CRT and 6 months after. Patients with a decrease in New York Heart Association (NYHA) functional class ≥ 1, a decrease in left ventricular end-systolic volume (LVESV) ≥ 15%, and a final left ventricular ejection fraction (LVEF) ≥ 45% were classified as SRs.
results29% of the 201 patients who underwent CRT were identified as SRs. At baseline, SRs had significantly smaller left atrial diameter (LAD), LVESV, left ventricular end-diastolic volume (LVEDV) and higher LVEF than the non-super-responders (non-SRs). The percentage of patients using angiotensin-converting enzyme inhibitors or angiotensin receptor blockers (ACEI/ARB) was higher in SRs than non-SRs. Most SRs had Biventricular (BiV) pacing percentage greater than 98% six months after CRT. In the multivariate logistic regression analysis, the independent predictors of SRs were lower LVEDV [odd ratios (OR): 0.93; confidence intervals (CI): 0.90-0.97], use of ACEI/ARB (OR: 0.33; CI: 0.13-0.82) and BiV pacing percentage greater than 98% (OR: 0.29; CI: 0.16-0.87).
conclusionPatients with a better compliance of ACEI/ARB and a less ectatic ventricular geometry before CRT tends to have a greater probability of becoming SRs. Higher percentage of BiV pacing is essential for becoming SRs.
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