Evidence map›Paper›PMID 29581620›Full record

ArticleNagoya journal of medical science2018

Genome-wide association study for pollinosis identified two novel loci in

Ryosuke Fujii, Asahi Hishida, Michael C Wu, Takaaki Kondo, Yuta Hattori, Mariko Naito, Kaori Endoh, Masahiro Nakatochi, Nobuyuki Hamajima, Michiaki Kubo and 2 more

Open access · greenAbstract read
In one paragraph

Article in Nagoya journal of medical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
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  4. Advances in asthma and allergic disease genetics: Is bigger always better?The Journal of allergy and clinical immunology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Ryosuke FujiiDepartment of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Asahi HishidaDepartment of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Michael C WuBiostatistics and Biomathematics Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, United States.
Takaaki KondoDepartment of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Yuta HattoriDepartment of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Mariko NaitoDepartment of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Kaori EndohLaboratory of Public Health, Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan.
Masahiro NakatochiCenter for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya, Japan.
Nobuyuki HamajimaDepartment of Health Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Michiaki KuboLaboratory for Genotyping Development, Center of Genomic Medicine, RIKEN, Yokohama, Japan.
Kiyonori KurikiLaboratory of Public Health, Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan.
Kenji WakaiDepartment of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Nagoya University · JPUniversity of Shizuoka · JPNagoya University Hospital · JPRIKEN Center for Integrative Medical Sciences · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The number of pollinosis patients in Japan has significantly increased over the past 20 years. The majority of genome-wide association studies (GWAS) on pollinosis have been conducted in subjects of European descent, with few studies in Japanese populations. The aim of our GWAS was to identify genetic loci associated with self-reported pollinosis in a Japanese population and to understand its molecular background using a combination of single nucleotide polymorphisms (SNPs) and gene- and pathway-based analyses. A total of 731 and 560 individuals who were recruited as participants of the Japan Multi-Institutional Collaborative Cohort Study participated in the discovery and replication phases, respectively. The phenotype of pollinosis was based on the information from a self-administered questionnaire. In the single-SNP analysis, four SNPs (rs11975199, rs11979076, rs11979422, and rs12669708) reached suggestive significance level (P < 1 × 10

Indexed as

AdultFemaleGenome-Wide Association StudyHumansInterleukin-1betaMaleMiddle AgedPolymorphism, Single NucleotideRhinitis, AllergicRhinitis, Allergic, SeasonalIL1B protein, humanInterleukin-1betaallergic rhinitiscedar pollinosiscypress pollinosisgenome-wide association studypollinosis

Identifiers

PMID29581620
PMCPMC5857507
OpenAlexW2795119399

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.