Evidence map›Paper›PMID 29581564›Full record

ArticleEuropean journal of clinical nutrition2018

Prognostic impact of early nutritional support in patients affected by locally advanced and metastatic pancreatic ductal adenocarcinoma undergoing chemotherapy.

Ilaria Trestini, Luisa Carbognin, Isabella Sperduti, Clelia Bonaiuto, Alessandra Auriemma, Davide Melisi, Lisa Salvatore, Emilio Bria, Giampaolo Tortora

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In one paragraph

Article in European journal of clinical nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Ilaria TrestiniU.O.C. Oncology, University of Verona Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
Luisa CarbogninU.O.C. Oncology, University of Verona Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
Isabella SperdutiDepartment of Biostatistics, Regina Elena National Cancer Institute, Roma, Italy.
Clelia BonaiutoU.O.C. Oncology, University of Verona Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
Alessandra AuriemmaU.O.C. Oncology, University of Verona Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
Davide MelisiU.O.C. Oncology, University of Verona Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
Lisa SalvatoreU.O.C. Oncology, University of Verona Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
Emilio BriaU.O.C. Oncology, University of Verona Azienda Ospedaliera Universitaria Integrata, Verona, Italy. emilio.bria@univr.it.
Giampaolo TortoraU.O.C. Oncology, University of Verona Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
Azienda Ospedaliera Universitaria Integrata Verona · ITUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesThe aim of this analysis was to determine the risk of malnutrition and the prognostic value of nutritional intervention in patients affected by pancreatic ductal adenocarcinoma (PDAC) undergoing chemotherapy. SUBJECTS/

methodsClinical-pathological and nutritional data were correlated with overall survival (OS) using a Cox model. Nutritional status was determined by Malnutrition Universal Screening Tool (MUST), body mass index, weight loss in the past 6 months, presence of nutrition-related symptoms, and current energy intake. Nutritional intervention included appropriate individual dietary counseling.

resultsData from 109 patients were gathered (median age 63 years). The majority of patients (64.2%) presented a MUST value of ≥ 2, corresponding to a high risk of malnutrition. At multivariate analysis for OS in locally advanced and metastatic PDAC patients, the time between the diagnosis and the nutritional intervention (HR 2.22, p = 0.017), the performance status (HR 1.38, p = 0.075), the surgery of the primary (HR 5.89, p = 0.005), and the response to the first line (HR 5.9, p = 0.03) were independent significant predictors of outcome. Furthermore, a weight gain > 2% from the baseline weight was correlated with the time between the diagnosis and the nutritional intervention (p = 0.021): in patients receiving a nutritional support within 3 months from diagnosis, a 2% weight gain was associated with a 2-year OS benefit (50.3% vs. 33.0%, p = 0.04).

conclusionsThis analysis suggests that the early nutritional support may contribute to influence the prognosis of patients affected by advanced PDAC undergoing chemotherapy.

Indexed as

Nutritional SupportAdultAgedAged, 80 and overBody Mass IndexCarcinoma, Pancreatic DuctalCounselingDietEarly DiagnosisEndpoint DeterminationFemaleFollow-Up StudiesHumansMaleMalnutritionMiddle Aged

Identifiers

PMID29581564
OpenAlexW2793956245

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.