ArticleNature nanotechnology2018
Nanoparticles as multimodal photon transducers of ionizing radiation.
Article in Nature nanotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 83 citations in OpenAlex.
- In vivo ultrasound-induced luminescence imaging via trianthracene derivatives nanomaterials.Nature protocols · 2026Review
- Radionuclide-stimulated dynamic therapy induces complementary immunogenic necroptosis and apoptosis cancer cell death pathways.Communications biology · 2026Article
- Improved X-ray absorption capability of Core-shell nano-transducer in situ enhances γ-ray-excited radioluminescence imaging in vivo.Journal of nanobiotechnology · 2026Article
- Enhanced Cerenkov radiation induced photodynamic therapy based on GSH-responsive biomimetic nanoplatform to trigger immunogenic cell death for tumor immunotherapy.Asian journal of pharmaceutical sciences · 2025Article
- Multiplexed imaging of radionuclides.Nature biomedical engineering · 2025Review
- Radiances of Cerenkov-Emitting Radionuclides on the In Vivo Imaging System.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025Article
- Amplification of Cerenkov luminescence using semiconducting polymers for cancer theranostics.Advanced functional materials · 2023Article
- Cancer Treatment Using Different Shapes of Gold-Based Nanomaterials in Combination with Conventional Physical Techniques.Pharmaceutics · 2023Review
- Detection of Shortwave-Infrared Cerenkov Luminescence from Medical Isotopes.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023Article
- Oxygen-evolving photosynthetic cyanobacteria for 2D bismuthene radiosensitizer-enhanced cancer radiotherapy.Bioactive materials · 2022Article
- Design Principles of Hybrid Nanomaterials for Radiotherapy Enhanced by Photodynamic Therapy.International journal of molecular sciences · 2022Review
- Antiandrogen Therapy Radiosensitizes Androgen Receptor-Positive Cancers toJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022Article
- Activation of nano-photosensitizers by Y-90 microspheres to enhance oxidative stress and cell death in hepatocellular carcinoma.Scientific reports · 2022Article
- Role of nanoparticles in transarterial radioembolization with glass microspheres.Annals of nuclear medicine · 2022Article
- Prospective testing of clinical Cerenkov luminescence imaging against standard-of-care nuclear imaging for tumour location.Nature biomedical engineering · 2022Observational
- Biomedical Applications of Lanthanide Nanomaterials, for Imaging, Sensing and Therapy.Nanotheranostics · 2022Review
- Cerenkov radiation-activated probes for deep cancer theranostics: a review.Theranostics · 2022Review
- Do Lipid-based Nanoparticles Hold Promise for Advancing the Clinical Translation of Anticancer Alkaloids?Cancers · 2021Review
- Radiopharmaceutical and EuJournal of nanobiotechnology · 2021Article
- Ultrasmall Downconverting Nanoparticle for Enhanced Cerenkov Imaging.Nano letters · 2021Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
In biomedical imaging, nanoparticles combined with radionuclides that generate Cerenkov luminescence are used in diagnostic imaging, photon-induced therapies and as activatable probes. In these applications, the nanoparticle is often viewed as a carrier inert to ionizing radiation from the radionuclide. However, certain phenomena such as enhanced nanoparticle luminescence and generation of reactive oxygen species cannot be completely explained by Cerenkov luminescence interactions with nanoparticles. Herein, we report methods to examine the mechanisms of nanoparticle excitation by radionuclides, including interactions with Cerenkov luminescence, β particles and γ radiation. We demonstrate that β-scintillation contributes appreciably to excitation and reactivity in certain nanoparticle systems, and that excitation by radionuclides of nanoparticles composed of large atomic number atoms generates X-rays, enabling multiplexed imaging through single photon emission computed tomography. These findings demonstrate practical optical imaging and therapy using radionuclides with emission energies below the Cerenkov threshold, thereby expanding the list of applicable radionuclides.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.