Evidence map›Paper›PMID 29581540›Full record

Observational studyScientific reports2018

Lower serum calcium is independently associated with CKD progression.

Cynthia J Janmaat, Merel van Diepen, Alessandro Gasparini, Marie Evans, Abdul Rashid Qureshi, Johan Ärnlöv, Peter Barany, Carl-Gustaf Elinder, Joris I Rotmans, Marc Vervloet and 2 more

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

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  12. Preclinical evaluation ofEuropean journal of nuclear medicine and molecular imaging · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Cynthia J JanmaatDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands. c.j.janmaat@lumc.nl.
Merel van DiepenDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Alessandro GaspariniDepartment of Clinical Science, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-8319-7624
Marie EvansDepartment of Clinical Science, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-8650-5795
Abdul Rashid QureshiDepartment of Clinical Science, Karolinska Institutet, Stockholm, Sweden.
Johan ÄrnlövDepartment of Clinical Science, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-6933-4637
Peter BaranyDepartment of Clinical Science, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-6501-8293
Carl-Gustaf ElinderDepartment of Clinical Science, Karolinska Institutet, Stockholm, Sweden.
Joris I RotmansDepartment of Nephrology, Leiden University Medical Center, Leiden, The Netherlands.
Marc VervloetDepartment of Nephrology and Institute for Cardiovascular Research VU, VU University Medical Center, Amsterdam, The Netherlands.
Friedo W DekkerDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Juan Jesus CarreroDepartment of Clinical Science, Karolinska Institutet, Stockholm, Sweden.
Karolinska Institutet · SELeiden University Medical Center · NLAmsterdam UMC Location Vrije Universiteit Amsterdam · NLStockholm County Council · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Disturbances in calcium metabolism are common in individuals with chronic kidney disease (CKD), but whether they are associated with subsequent kidney function decline is less clear. In a CKD 3-5 cohort of 15,755 adult citizens of Stockholm with creatinine tests taken during 2006-2011 and concurrent calcium testing at cohort entry, we investigated the association between baseline serum calcium and the subsequent change in estimated glomerular filtration rate (eGFR, by CKD-EPI) decline using linear mixed models. Mean (SD) baseline corrected serum calcium was 9.6 (0.5) mg/dL. Mean (95%-confidence interval [CI]) eGFR decline was -0.82 (-0.90; -0.74) mL/min/1.73 m

Indexed as

Disease ProgressionGlomerular Filtration RateAgedAged, 80 and overCalciumCohort StudiesFemaleFollow-Up StudiesHumansKidneyLinear ModelsMaleMiddle AgedMultivariate AnalysisRenal Insufficiency, ChronicRisk FactorsCalciumVitamin D

Identifiers

PMID29581540
PMCPMC5980097
OpenAlexW2793753590

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.