Evidence map›Paper›PMID 29581537›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2018

M

Sean P Moran, Jonathan W Dickerson, Hyekyung P Cho, Zixiu Xiang, James Maksymetz, Daniel H Remke, Xiaohui Lv, Catherine A Doyle, Deepa H Rajan, Colleen M Niswender and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 80 citations in OpenAlex.

  1. Trial
  2. Trial
  3. ACS medicinal chemistry letters · 2026
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  6. Discovery of VU6052254: A Novel, Potent MACS chemical neuroscience · 2025
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  7. Article
  8. Discovery of a Novel spACS medicinal chemistry letters · 2025
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  9. Application of Deuterium in an MACS chemical neuroscience · 2025
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  10. Article
  11. Discovery of VU0467319: an MACS chemical neuroscience · 2025
    Article
  12. Review
  13. Anticholinergic drugs for parkinsonism and other movement disorders.Journal of neural transmission (Vienna, Austria : 1996) · 2024
    Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. The Partial MACS chemical neuroscience · 2023
    Article
  19. MProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  20. MScience signaling · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Sean P MoranVanderbilt Brain Institute, Vanderbilt University, Nashville, TN, 37232, USA.
Jonathan W DickersonDepartment of Pharmacology, Vanderbilt University, Nashville, TN, 37232, USA.
Hyekyung P ChoDepartment of Pharmacology, Vanderbilt University, Nashville, TN, 37232, USA.
Zixiu XiangDepartment of Pharmacology, Vanderbilt University, Nashville, TN, 37232, USA.ORCID http://orcid.org/0000-0002-1678-209X
James MaksymetzDepartment of Pharmacology, Vanderbilt University, Nashville, TN, 37232, USA.
Daniel H RemkeDepartment of Pharmacology, Vanderbilt University, Nashville, TN, 37232, USA.
Xiaohui LvDepartment of Pharmacology, Vanderbilt University, Nashville, TN, 37232, USA.
Catherine A DoyleDepartment of Pharmacology, Vanderbilt University, Nashville, TN, 37232, USA.
Deepa H RajanDepartment of Pharmacology, Vanderbilt University, Nashville, TN, 37232, USA.
Colleen M NiswenderDepartment of Pharmacology, Vanderbilt University, Nashville, TN, 37232, USA.
Darren W EngersDepartment of Pharmacology, Vanderbilt University, Nashville, TN, 37232, USA.
Craig W LindsleyDepartment of Pharmacology, Vanderbilt University, Nashville, TN, 37232, USA.
Jerri M RookDepartment of Pharmacology, Vanderbilt University, Nashville, TN, 37232, USA.
P Jeffrey ConnVanderbilt Brain Institute, Vanderbilt University, Nashville, TN, 37232, USA. jeffrey.conn@vanderbilt.edu.
Vanderbilt University · US

Funding

REGULATION OF SIGNALING BY MGLUR5R01MH062646 · NIMH · VANDERBILT UNIVERSITY · PI P Jeffrey Conn, COLLEEN M NISWENDER · 2001 to 2026
$10.9M
Vanderbilt NCDDDG for Discovery of Novel Treatments for SchizophreniaU01MH087965 · NIMH · VANDERBILT UNIVERSITY · PI LINDSLEY, CRAIG · 2010 to 2014
$9.3M
Muscarinic receptor activators as novel antipsychotic agentsR01MH073676 · NIMH · VANDERBILT UNIVERSITY · PI Jerri Michelle Rook · 2006 to 2026
$9.3M
Training in Fundamental NeuroscienceT32MH064913 · NIMH · VANDERBILT UNIVERSITY · PI IHRIE, REBECCA A, WINDER, DANNY G. · 2001 to 2022
$7.6M
Research Project: Sensory and Multisensory Contributions to AutismU54HD083211 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DYKENS, ELISABETH MAY · 2015 to 2019
$7.1M
Safety and tolerability testing of VU0467319: an M1 PAM for clinical developmentU19MH106839 · NIMH · VANDERBILT UNIVERSITY · PI CONN, P JEFFREY · 2015 to 2017
$5.3M
Selective M1 mAChR allosteric modulators for the treatment of schizophreniaR01MH082867 · NIMH · VANDERBILT UNIVERSITY · PI LINDSLEY, CRAIG · 2008 to 2017
$3.7M
Role of Phospholipase D in M1 Allosteric Modulation of Synaptic Plasticity: Implications for the Treatment of SchizophreniaF31MH114368 · NIMH · VANDERBILT UNIVERSITY · PI MORAN, SEAN PATRICK · 2017 to 2019
$71k
NICHD NIH HHS U54 HD083211NIMH NIH HHS F31 MH114368NIMH NIH HHS R01 MH062646NIMH NIH HHS R01 MH073676NIMH NIH HHS R01 MH082867NIMH NIH HHS T32 MH064913NIMH NIH HHS U01 MH087965NIMH NIH HHS U19 MH106839
6 · The paper itself

Abstract

Highly selective positive allosteric modulators (PAMs) of the M

Indexed as

Allosteric RegulationAnimalsCHO CellsCholinergic AgentsCricetulusExcitatory Postsynaptic PotentialsMaleMice, Inbred C57BLNootropic AgentsPrefrontal CortexPyramidal CellsRatsRats, Sprague-DawleyReceptor, Muscarinic M1Recognition, PsychologyTissue Culture TechniquesCholinergic AgentsNootropic AgentsReceptor, Muscarinic M1

Identifiers

PMID29581537
PMCPMC6006294
OpenAlexW2791870770

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.