ArticleScientific reports2018
Long term potentiation, but not depression, in interlamellar hippocampus CA1.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- Optogenetics reveals paradoxical network stabilizations in hippocampal CA1 and CA3.Current biology : CB · 2023Article
- Hippocampal interlamellar cell-cell connectome that counts.Journal of cellular physiology · 2022Review
- A realistic morpho-anatomical connection strategy for modelling full-scale point-neuron microcircuits.Scientific reports · 2022Article
- Altered synaptic plasticity of the longitudinal dentate gyrus network in noise-induced anxiety.iScience · 2022Article
- Electroacupuncture Enhances Cognitive Deficits in a Rat Model of Rapid Eye Movement Sleep Deprivation via Targeting MiR-132.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Impairment of synaptic plasticity and novel object recognition in the hypergravity-exposed rats.Scientific reports · 2020Article
- Changes in Hippocampal Plasticity in Depression and Therapeutic Approaches Influencing These Changes.Neural plasticity · 2020Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synaptic plasticity in the lamellar CA3 to CA1 circuitry has been extensively studied while interlamellar CA1 to CA1 connections have not yet received much attention. One of our earlier studies demonstrated that axons of CA1 pyramidal neurons project to neighboring CA1 neurons, implicating information transfer along a longitudinal interlamellar network. Still, it remains unclear whether long-term synaptic plasticity is present within this longitudinal CA1 network. Here, we investigate long-term synaptic plasticity between CA1 pyramidal cells, using in vitro and in vivo extracellular recordings and 3D holography glutamate uncaging. We found that the CA1-CA1 network exhibits NMDA receptor-dependent long-term potentiation (LTP) without direction or layer selectivity. By contrast, we find no significant long-term depression (LTD) under various LTD induction protocols. These results implicate unique synaptic properties in the longitudinal projection suggesting that the interlamellar CA1 network could be a promising structure for hippocampus-related information processing and brain diseases.
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