ArticleScientific reports2018
Dietary genistein supplementation for breeders and their offspring improves the growth performance and immune function of broilers.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 46 citations in OpenAlex.
- Effects of dietaryFrontiers in nutrition · 2026Article
- Genistein supplementation attenuates arsenic-triggered neurobehavioral deficits and ER stress-associated gene dysregulation in Nile tilapia.Fish physiology and biochemistry · 2025Article
- Walnut Green Husk Extract Enhances Antioxidant, Anti-Inflammatory, and Immune Functions by Regulating Gut Microbiota and Metabolites in Fattening Pigs.Animals : an open access journal from MDPI · 2025Article
- Research advances in intramuscular fat deposition and chicken meat quality: genetics and nutrition.Journal of animal science and biotechnology · 2025Review
- Maternal supplementation with mulberry-leaf flavonoids improves the development of skeletal muscle in the offspring of chickens.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2024Article
- Genistein Promotes M2 Macrophage Polarization via Aryl Hydrocarbon Receptor and Alleviates Intestinal Inflammation in Broilers with Necrotic Enteritis.International journal of molecular sciences · 2024Article
- Effects of DietaryAntioxidants (Basel, Switzerland) · 2024Article
- Effects of Six Natural Compounds and Their Derivatives on the Control of Coccidiosis in Chickens.Microorganisms · 2024Article
- Effects of dietary genistin supplementation on reproductive performance, immunity and antioxidative capacity in gestating sows.Frontiers in veterinary science · 2024Article
- Whole-genome sequencing revealed genetic diversity, structure and patterns of selection in Guizhou indigenous chickens.BMC genomics · 2023Article
- Supplementing Genistein for Breeder Hens Alters the Growth Performance and Intestinal Health of Offspring.Life (Basel, Switzerland) · 2023Article
- Effect of bacillus subtilis strain Z15 secondary metabolites on immune function in mice.BMC genomics · 2023Article
- Dietary Epimedium extract supplementation improves intestinal functions and alters gut microbiota in broilers.Journal of animal science and biotechnology · 2023Article
- Effects of dietary supplementation with dandelion tannins or soybean isoflavones on growth performance, antioxidant function, intestinal morphology, and microbiota composition in Wenchang chickens.Frontiers in veterinary science · 2022Article
- Intraperitoneal injection of genistein affects the distribution and metabolism of cholesterol in female yellow catfish Tachysurus fulvidraco.Fish physiology and biochemistry · 2021Article
- Dietary genistein supplementation protects against lipopolysaccharide-induced intestinal injury through altering transcriptomic profile.Poultry science · 2020Article
- Oral Exposure to Genistein during Conception and Lactation Period Affects the Testicular Development of Male Offspring Mice.Animals : an open access journal from MDPI · 2020Article
- Effect of Soybean Isoflavones on Growth Performance, Immune Function, and Viral Protein 5 mRNA Expression in Broiler Chickens Challenged with Infectious Bursal Disease Virus.Animals : an open access journal from MDPI · 2019Article
- Supplementing Genistein for Breeder Hens Alters the Fatty Acid Metabolism and Growth Performance of Offsprings by Epigenetic Modification.Oxidative medicine and cellular longevity · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genistein (GEN) is mainly extracted from soy plants and has potential functions as an antioxidant and in promoting immune function and growth. This study evaluated the effects of feeding breeders and their offspring dietary GEN on the immune function and growth performance of broiler chicks. Breeders were assigned to a control diet or GEN diet (control diet +400 mg/kg GEN), and their offspring were fed a control diet or GEN diet (control diet +40 mg/kg GEN). GEN treatment increased the body weight gain, tibial length, tibial width and slaughter performance of broilers and decreased the feed conversion ratio. The treatment also affected skeletal muscle myosin assembly and growth and increased growth hormone levels and IGF-I and IGFBP1 expression. Following GEN treatment, antigen processing and presentation, macrophage activation, B lymphocyte, NK cell and helper T cell proliferation, and CD4+ T lymphocyte differentiation all increased significantly. Increases were also observed in IgM and IgG concentrations, antibody titers, and antioxidant capacity. In addition, GEN treatment activated the Toll-like receptor signaling pathway and MAPK cascade signaling pathway. In summary, dietary GEN supplementation for breeders and their offspring can improve the growth performance and immune function of broiler chicks.
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