Evidence map›Paper›PMID 29581428›Full record

ArticleNature communications2018

Divergent midbrain circuits orchestrate escape and freezing responses to looming stimuli in mice.

Congping Shang, Zijun Chen, Aixue Liu, Yang Li, Jiajing Zhang, Baole Qu, Fei Yan, Yaning Zhang, Weixiu Liu, Zhihui Liu and 4 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 151 papers.

0numbers the graph read from it
0cells of the map it votes in
151citing papers in PubMed
10.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

151 citing papers in PubMed, 261 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. A Neurotensin Brake on Exploratory Drive under Persistent Threat.bioRxiv : the preprint server for biology · 2026
    Article
  8. Ecological Visual Processing in the Mouse.Annual review of neuroscience · 2026
    Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Midbrain PAG Astrocytes Modulate Mouse Defensive and Panic-Like Behaviors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  18. Article
  19. Article
  20. Article

91 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Congping ShangState Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China.
Zijun ChenState Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China.
Aixue LiuNational Institute of Biological Sciences, 102206, Beijing, China.
Yang LiNational Institute of Biological Sciences, 102206, Beijing, China.
Jiajing ZhangState Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China.
Baole QuState Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China.
Fei YanState Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China.
Yaning ZhangPTN Graduate Programs, School of Life Sciences, Tsinghua University, 100084, Beijing, China.
Weixiu LiuPTN Graduate Programs, School of Life Sciences, Tsinghua University, 100084, Beijing, China.
Zhihui LiuState Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China.
Xiaofei GuoState Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China.
Dapeng LiNational Institute of Biological Sciences, 102206, Beijing, China.
Yi WangState Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China.
Peng CaoState Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China. caopeng@nibs.ac.cn.ORCID http://orcid.org/0000-0001-7739-6857
Chinese Academy of Sciences · CNNational Institute of Biological Sciences, Beijing · CNChinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Animals respond to environmental threats, e.g. looming visual stimuli, with innate defensive behaviors such as escape and freezing. The key neural circuits that participate in the generation of such dimorphic defensive behaviors remain unclear. Here we show that the dimorphic behavioral patterns triggered by looming visual stimuli are mediated by parvalbumin-positive (PV

Indexed as

Escape ReactionFreezing Reaction, CatalepticPhotic StimulationAnimalsFearLateral Thalamic NucleiMaleMesencephalonMiceMice, Inbred C57BLNeuronsSuperior ColliculiVisual Pathways

Identifiers

PMID29581428
PMCPMC5964329
OpenAlexW2794918217

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.