ArticleTranslational psychiatry2018
Low-frequency and rare variants may contribute to elucidate the genetics of major depressive disorder.
Article in Translational psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Kernel-based gene-environment interaction tests for rare variants with multiple quantitative phenotypes.PloS one · 2022Pooled it
- Variance-component-based meta-analysis of gene-environment interactions for rare variants.G3 (Bethesda, Md.) · 2021Pooled it
- A unified method for rare variant analysis of gene-environment interactions.Statistics in medicine · 2020Pooled it
- Rare Functional Variants Associated with Antidepressant Remission in Mexican-Americans: Short title: Antidepressant remission and pharmacogenetics in Mexican-Americans.Journal of affective disorders · 2021Trial
- A rare variant inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Identification of a strong genetic risk factor for major depressive disorder in the human virome.iScience · 2024Article
- Cauchy combination methods for the detection of gene-environment interactions for rare variants related to quantitative phenotypes.Heredity · 2023Article
- Convergent selective signaling impairment exposes the pathogenicity of latrophilin-3 missense variants linked to inheritable ADHD susceptibility.Molecular psychiatry · 2022Article
- Targeted sequencing of the BDNF gene in young Chinese Han people with major depressive disorder.Molecular genetics & genomic medicine · 2020Article
- Imputation of 3 million SNPs in the Arabidopsis regional mapping population.The Plant journal : for cell and molecular biology · 2020Article
- Weighted Gene Coexpression Network Analysis Identifies Specific Modules and Hub Genes Related to Major Depression.Neuropsychiatric disease and treatment · 2020Article
- Genetic effects on white matter integrity in drug-naive patients with major depressive disorder: a diffusion tensor imaging study of 17 genetic loci associated with depressive symptoms.Neuropsychiatric disease and treatment · 2019Article
- A single-nucleotide polymorphism influences brain morphology in drug-naïve patients with major depressive disorder.Neuropsychiatric disease and treatment · 2019Article
- iMEGES: integrated mental-disorder GEnome score by deep neural network for prioritizing the susceptibility genes for mental disorders in personal genomes.BMC bioinformatics · 2018Article
- Genetic and Epigenetic Alterations Underlie Oligodendroglia Susceptibility and White Matter Etiology in Psychiatric Disorders.Frontiers in genetics · 2018Review
- Influence of functional gene polymorphisms on human behaviour: the case ofJournal of psychiatry & neuroscience : JPNArticle
- Heterogeneity and Polygenicity in Psychiatric Disorders: A Genome-Wide Perspective.Chronic stress (Thousand Oaks, Calif.)Review
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7 authors.
Funding
Abstract
Major depressive disorder (MDD) is a common but serious psychiatric disorder with significant levels of morbidity and mortality. Recent genome-wide association studies (GWAS) on common variants increase our understanding of MDD; however, the underlying genetic basis remains largely unknown. Many studies have been proposed to explore the genetics of complex diseases from a viewpoint of the "missing heritability" by considering low-frequency and rare variants, copy-number variations, and other types of genetic variants. Here we developed a novel computational and statistical strategy to investigate the "missing heritability" of MDD. We applied Hamming distance on common, low-frequency, and rare single-nucleotide polymorphism (SNP) sets to measure genetic distance between two individuals, and then built the multi-dimensional scaling (MDS) pictures. Whole-exome genotyping data from a Los Angeles Mexican-American cohort (203 MDD and 196 controls) and a European-ancestry cohort (473 MDD and 497 controls) were examined using our proposed methodology. MDS plots showed very significant separations between MDD cases and healthy controls for low-frequency SNP set (P value < 2.2e-16) and rare SNP set (P value = 7.681e-12). Our results suggested that low-frequency and rare variants may play more significant roles in the genetics of MDD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.