ArticleTranslational psychiatry2018
Lateral habenula perturbation reduces default-mode network connectivity in a rat model of depression.
Article in Translational psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- The habenula in mood disorders: A systematic review of human studies.Molecular psychiatry · 2025Pooled it
- Synaptic Plasticity-Intrinsic Excitability and Antidepressant Discovery.Biomedicines · 2026Review
- Ventral pallidum efferent pathways via mediodorsal thalamus and lateral habenula mediate default mode network regulation.iScience · 2025Article
- Altered habenular and whole brain functional connectivity in early Parkinson's disease using 7 T MRI.NPJ Parkinson's disease · 2025Article
- Blue light influences negative thoughts of self.Sleep · 2025Article
- Mesoscale brain-wide fluctuation analysis: revealing ketamine's rapid antidepressant across multiple brain regions.Translational psychiatry · 2025Article
- Safety and precision of frontal trajectory of lateral habenula deep brain stimulation surgery in treatment-resistant depression.Frontiers in neurology · 2023Article
- TRIAC Treatment Improves Impaired Brain Network Function and White Matter Loss in Thyroid Hormone Transporter Mct8/Oatp1c1 Deficient Mice.International journal of molecular sciences · 2022Article
- Social defeat drives hyperexcitation of the piriform cortex to induce learning and memory impairment but not mood-related disorders in mice.Translational psychiatry · 2022Article
- Alterations to cognitive abilities and functional networks in rats post broad-band intense noise exposure.Brain imaging and behavior · 2022Article
- Striatal hub of dynamic and stabilized prediction coding in forebrain networks for olfactory reinforcement learning.Nature communications · 2022Article
- Prospects for improved prevention and treatment of neuropsychiatric disorders:Neuroscience applied · 2022Article
- Multi-level variations of lateral habenula in depression: A comprehensive review of current evidence.Frontiers in psychiatry · 2022Review
- miR-323a regulates ERBB4 and is involved in depression.Molecular psychiatry · 2021Article
- The combination of fluoxetine and environmental enrichment reduces postpartum stress-related behaviors through the oxytocinergic system and HPA axis in mice.Scientific reports · 2021Article
- Electrophysiological Correlates of Rodent Default-Mode Network Suppression Revealed by Large-Scale Local Field Potential Recordings.Cerebral cortex communications · 2021Article
- Total Recall: Lateral Habenula and Psychedelics in the Study of Depression and Comorbid Brain Disorders.International journal of molecular sciences · 2020Review
- Altered directed functional connectivity of the right amygdala in depression: high-density EEG study.Scientific reports · 2020Article
- Can Intraoperative Low-DoseFrontiers in pharmacology · 2020Review
- Case Report: Lateral Habenula Deep Brain Stimulation for Treatment-Resistant Depression.Frontiers in psychiatry · 2020Article
Corrections and comments
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Authors and funding
16 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyperconnectivity of the default-mode network (DMN) is one of the most widely replicated neuroimaging findings in major depressive disorder (MDD). Further, there is growing evidence for a central role of the lateral habenula (LHb) in the pathophysiology of MDD. There is preliminary neuroimaging evidence linking LHb and the DMN, but no causal relationship has been shown to date. We combined optogenetics and functional magnetic resonance imaging (fMRI), to establish a causal relationship, using an animal model of treatment-resistant depression, namely Negative Cognitive State rats. First, an inhibitory light-sensitive ion channel was introduced into the LHb by viral transduction. Subsequently, laser stimulation was performed during fMRI acquisition on a 9.4 Tesla animal scanner. Neural activity and connectivity were assessed, before, during and after laser stimulation. We observed a connectivity decrease in the DMN following laser-induced LHb perturbation. Our data indicate a causal link between LHb downregulation and reduction in DMN connectivity. These findings may advance our mechanistic understanding of LHb inhibition, which had previously been identified as a promising therapeutic principle, especially for treatment-resistant depression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.