ArticleTranslational psychiatry2018
Aberrant salience network functional connectivity in auditory verbal hallucinations: a first episode psychosis sample.
Article in Translational psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 90 citations in OpenAlex.
- Functional brain connectivity in clinical high-risk youth from the Kenya psychosis-risk outcomes study (KePROS): functional network comparative area and topography analysis (FUNCATA).NeuroImage. Clinical · 2026Article
- From neuronal to mental topography - Neurophenomenology of auditory hallucinations.Translational psychiatry · 2025Review
- Network localization of genetic risk for schizophrenia and bipolar disorder.Psychological medicine · 2025Article
- Targeting the Roots of Psychosis: The Role of Aberrant Salience.Pediatric reports · 2025Review
- Study on Large-Scale Brain Network Abnormalities in Patients With Beta-Thalassemia.Brain and behavior · 2025Article
- Connectome-based predictive modeling of early and chronic psychosis symptoms.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Effective Stimulation Sites and Networks for Substantia Nigra Pars Reticulata Deep Brain Stimulation for Auditory Verbal Hallucinations in Schizophrenia.medRxiv : the preprint server for health sciences · 2025Article
- A working model of neural activity and phenomenal experience in psychosis.Molecular psychiatry · 2024Review
- Network Localization of State and Trait of Auditory Verbal Hallucinations in Schizophrenia.Schizophrenia bulletin · 2024Article
- Latent profile analysis identifies four different clinical schizophrenia profiles through aberrant salience.Schizophrenia (Heidelberg, Germany) · 2024Article
- Functional Connectivity of the Auditory Cortex in Women With Trauma-Related Disorders Who Hear Voices.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Insomnia in Forensic Detainees: Is Salience Network the Common Pathway for Sleep, Neuropsychiatric, and Neurodegenerative Disorders?Journal of clinical medicine · 2024Review
- Functional Connectivity of Language-Related Cerebellar Regions Is Reduced in Schizophrenia Patients.Biomedicines · 2024Article
- Low-frequency rTMS induces modifications in cortical structural connectivity - functional connectivity coupling in schizophrenia patients with auditory verbal hallucinations.Human brain mapping · 2024Article
- Aberrant brain dynamics in individuals with clinical high risk of psychosis.Schizophrenia bulletin open · 2024Article
- Opposite effects of positive and negative symptoms on resting-state brain networks in schizophrenia.Communications biology · 2023Article
- Intrinsic Therapeutic Link between Recuperative Cerebellar Con-Nectivity and Psychiatry Symptom in Schizophrenia Patients with Comorbidity of Metabolic Syndrome.Life (Basel, Switzerland) · 2023Article
- Structural brain abnormalities in schizophrenia patients with a history and presence of auditory verbal hallucination.Translational psychiatry · 2022Article
- Trait related aberrant connectivity in clinically stable patients with schizophrenia: A seed based resting state fMRI study.Brain imaging and behavior · 2022Article
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Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Auditory verbal hallucinations (AVH) often lead to distress and functional disability, and are frequently associated with psychotic illness. Previously both state and trait magnetic resonance imaging (MRI) studies of AVH have identified activity in brain regions involving auditory processing, language, memory and areas of default mode network (DMN) and salience network (SN). Current evidence is clouded by research mainly in participants on long-term medication, with chronic illness and by choice of seed regions made 'a priori'. Thus, the aim of this study was to elucidate the intrinsic functional connectivity in patients presenting with first episode psychosis (FEP). Resting state functional MRI data were available from 18 FEP patients, 9 of whom also experienced AVH of sufficient duration in the scanner and had symptom capture functional MRI (sc fMRI), together with 18 healthy controls. Symptom capture results were used to accurately identify specific brain regions active during AVH; including the superior temporal cortex, insula, precuneus, posterior cingulate and parahippocampal complex. Using these as seed regions, patients with FEP and AVH showed increased resting sb-FC between parts of the SN and the DMN and between the SN and the cerebellum, but reduced sb-FC between the claustrum and the insula, compared to healthy controls.It is possible that aberrant activity within the DMN and SN complex may be directly linked to impaired salience appraisal of internal activity and AVH generation. Furthermore, decreased intrinsic functional connectivity between the claustrum and the insula may lead to compensatory over activity in parts of the auditory network including areas involved in DMN, auditory processing, language and memory, potentially related to the complex and individual content of AVH when they occur.
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