One Intact Transmembrane Substrate Binding Site Is Sufficient for the Function of the Homodimeric Type I ATP-Binding Cassette Importer for Positively Charged Amino Acids Art(MP)

Johanna Heuveling, Heidi Landmesser, Erwin Schneider

Open access · bronzeAbstract read

In one paragraph

Article in Journal of bacteriology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it

0cells of the map it votes in

3citing papers in PubMed

0.2field-weighted citation impact, top 44% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

Domestic pig skin peptides: targeted starvation therapy for gram-positive bacteria MRSA through ABC transporters.BMC microbiology · 2026
Article
Design and synthesis of an erdafitinib-based selective FGFR2 degrader.Beilstein journal of organic chemistry · 2026
Article
Evidence from Mutational Analysis for a Single Transmembrane Substrate Binding Site in the Histidine ATP-Binding Cassette Transporter of Salmonella enterica Serovar Typhimurium.Journal of bacteriology · 2019
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Johanna HeuvelingInstitut für Biologie, Physiologie der Mikroorganismen, Humboldt-Universität zu Berlin, Berlin, Germany.

Heidi LandmesserInstitut für Biologie, Physiologie der Mikroorganismen, Humboldt-Universität zu Berlin, Berlin, Germany.

Erwin SchneiderInstitut für Biologie, Physiologie der Mikroorganismen, Humboldt-Universität zu Berlin, Berlin, Germany erwin.schneider@rz.hu-berlin.de.ORCID 0000-0002-2980-3208

Humboldt-Universität zu Berlin · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ATP-binding cassette (ABC) transport systems comprise two transmembrane domains/subunits that form a translocation path and two nucleotide-binding domains/subunits that bind and hydrolyze ATP. Prokaryotic canonical ABC import systems require an extracellular substrate-binding protein for function. Knowledge of substrate-binding sites within the transmembrane subunits is scarce. Recent crystal structures of the ABC importer Art(QN)

Indexed as

Amino Acid MotifsAmino Acids, BasicATP-Binding Cassette TransportersBacterial ProteinsBinding SitesDimerizationGeobacillus stearothermophilusAmino Acids, BasicATP-Binding Cassette TransportersBacterial ProteinsATP-binding cassette transportersGeobacillus stearothermophilusmutational analysistransmembrane substrate binding sitestype I ABC importer

Identifiers

PMID29581409

DOI10.1128/JB.00092-18

PMCPMC5971484

OpenAlexW2795098443

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.