Evidence map›Paper›PMID 29581378›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018

HIPK2-Mediated Transcriptional Control of NMDA Receptor Subunit Expression Regulates Neuronal Survival and Cell Death.

Yulei Shang, Jiasheng Zhang, Eric J Huang

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Review
  3. HIPK2 in the physiology of nervous system and its implications in neurological disorders.Biochimica et biophysica acta. Molecular cell research · 2023
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Loss of HIPK2 Protects Neurons from Mitochondrial Toxins by Regulating Parkin Protein Turnover.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Yulei ShangDepartment of Pathology, University of California-San Francisco, San Francisco, California 94143 and.
Jiasheng ZhangDepartment of Pathology, University of California-San Francisco, San Francisco, California 94143 and.ORCID 0000-0001-6097-1384
Eric J HuangDepartment of Pathology, University of California-San Francisco, San Francisco, California 94143 and eric.huang2@ucsf.edu.ORCID 0000-0002-5381-3801
San Francisco VA Medical Center · USUniversity of California, San Francisco · US

Funding

Mechanisms of HIPK2 in neurodegenerationR01NS098516 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, ERIC J · 2016 to 2020
$1.7M
Mechanisms of ER Stress and Neurodegeneration in Parkinson's DiseaseI01BX001108 · VA · VETERANS AFFAIRS MED CTR SAN FRANCISCO · PI Eric J Huang · 2011 to 2026
–
BLRD VA I01 BX001108NINDS NIH HHS R01 NS098516
6 · The paper itself

Abstract

NMDA receptors are critical for neuronal communication. Dysfunction in NMDA receptors has been implicated in neuropsychiatric diseases. While it is well recognized that the composition of NMDA receptors undergoes a GluN2B-to-GluN2A switch in early postnatal life, the mechanism regulating this switch remains unclear. Using transcriptomic and functional analyses in brain tissues from male and female

Indexed as

AnimalsBrainCarrier ProteinsCell DeathCells, CulturedChlorocebus aethiopsCOS CellsCyclic AMP Response Element-Binding ProteinFemaleHEK293 CellsHumansMaleMAP Kinase Kinase 4MAP Kinase Signaling SystemMiceMice, Inbred C57BLCarrier ProteinsCyclic AMP Response Element-Binding ProteinHipk2 protein, mouseMAP Kinase Kinase 4Mitogen-Activated Protein Kinase 3NR2C NMDA receptorProtein Serine-Threonine KinasesReceptors, N-Methyl-D-AspartateRNA, MessengerHIPK2JNKNMDA receptorsubunitsurvivaltranscription

Identifiers

PMID29581378
PMCPMC5907057
OpenAlexW2791626349

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.